Results 331 to 340 of about 916,035 (361)

The Role of Diacylglycerol Kinases in T Cell Anergy

2008
Engagement of the T cell antigen receptor (TCR) results in the activation of multiple biochemical second messenger cascades that must be integrated for the appropriate T cell response. Once the critical TCR-stimulated signaling pathway is initiated by activation of protein tyrosine kinases, a series of adapter proteins is recruited that brings tyrosine-
Gary A. Koretzky, Xiao-Ping Zhong, Benjamin A. Olenchock   +2 more
openaire   +3 more sources

[17] Diacylglycerol kinase from escherichia coli

1992
Publisher Summary Diacylglycerol kinases (DG kinases) catalyze the ATP-dependent phosphorylation of sn -l,2-diacylglycerols. Escherichia coli DG kinase functions to recycle diacylglycerol (DAG), which is generated largely as a by-product of membrane-derived oligosaccharide biosynthesis.
Robert M. Bell, James P. Walsh
openaire   +3 more sources

Diacylglycerol Kinase in T Cell Anergy

Science's STKE, 2006
Defective Ras signaling contributes to T cell anergy, which occurs when T cells are presented with antigens in the absence of costimulatory signals and leads to T cells’ unresponsiveness to subsequent stimulation. T cell anergy is a key mechanism by which inappropriate immune responses are prevented.
openaire   +2 more sources

Diacylglycerols and Protein Kinase-C

1989
There is now much evidence to suggest that protein kinase-C (PKC) acts as a transducer element in cell-signalling processes following stimulation of membrane receptors linked to phospholipase(s)-C (PLC). Occupancy of such receptors by specific agonists (hormones, neurotransmitters, growth factors etc.) promotes hydrolysis by PLC of the membrane ...
openaire   +2 more sources

Regulation of diacylglycerol kinase by phosphorylation

Advances in Biological Regulation, 2012
M. Ikeda, Yasuhito Shirai, Naoaki Saito
openaire   +2 more sources

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Helgi B Schiöth, Misty M Attwood, Stefan Knapp   +2 more
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer

Molecular Carcinogenesis, 2017
M. Kai, Eiichiro Yamamoto, Akiko Sato, H. Yamano, T. Niinuma, Hiroshi Kitajima, Taku Harada, Hironori Aoki, R. Maruyama, M. Toyota, Tomo Hatahira, H. Nakase, T. Sugai, T. Yamashita, M. Toyota, Hiromu Suzuki   +15 more
semanticscholar   +1 more source

Diacylglycerol Kinase

2016
Tomoyuki Nakano, Kaoru Goto
openaire   +1 more source

Regulation and Functions of Diacylglycerol Kinases

Chemical Reviews, 2011
Yulia V. Shulga, Richard M. Epand, Matthew K. Topham   +2 more
openaire   +3 more sources