Results 41 to 50 of about 458,902 (268)

Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study

Viruses
In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on
Miriam Latorre-Millán, María Mar Rodríguez del Águila, Laura Clusa, Clara Mazagatos, Amparo Larrauri, María Amelia Fernández, Antonio Rezusta, Ana María Milagro   +7 more
doaj   +1 more source

The application of traditional machine learning and deep learning techniques in mammography: a review

Frontiers in Oncology, 2023
Breast cancer, the most prevalent malignant tumor among women, poses a significant threat to patients’ physical and mental well-being. Recent advances in early screening technology have facilitated the early detection of an increasing number of breast ...
Ying’e Gao, Jingjing Lin, Yuzhuo Zhou, Rongjin Lin, Rongjin Lin   +4 more
doaj   +1 more source

Dürer's diagnoses [PDF]

Nature, 1998
The faces of the four apostles in Durer's painting speak volumes about the saints' temperaments. This is no accident, as the artist was following the Renaissance medical theory of the four humours.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Application of Flow Cytometry in the Diagnosis of Bovine Epidemic Disease

Viruses, 2023
As science and technology continue to advance, the use of flow cytometry is becoming more widespread. It can provide important information about cells in the body by detecting and analysing them, thereby providing a reliable basis for disease diagnosis ...
Zhilin Liu, Yuliang Zhang, Donghui Zhao, Yunjiao Chen, Qinglei Meng, Xin Zhang, Zelin Jia, Jiayu Cui, Xueli Wang   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

External Cervical Resorption—The Commonly Misdiagnosed, Destructive Resorption—A Pilot Study

Medical Sciences Forum, 2023
External cervical resorption is a relatively uncommon, often misdiagnosed, destructive form of external resorption. It consists of an uncontrolled growth of resorptive tissue and consequent loss of mineralized tooth tissue, in an apical direction.
Marta Alves Duarte, João Albernaz Neves
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Interpretable machine learning models to predict survival in esophageal cancer: a study based on the SEER database and external validation in China

Frontiers in Physiology
ObjectiveWe developed interpretable machine learning (ML) models to predict the overall survival (OS) of esophageal cancer patients. This approach aims to make our modeling results more interpretable and transparent.MethodsWe collected the ...
Abudouresuli Tuersun, Abudouresuli Tuersun, Abudouresuli Tuersun, Saimaitikari Abudoubari, Saimaitikari Abudoubari, Saimaitikari Abudoubari, Abudoushalamu Abudouwake, Huerxidan Tuerdi, Abulizi Maimaitiyiming, Pahatijiang Nijiati, Ya Qiu, Ya Qiu, Jianquan Wang, Jianquan Wang   +13 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source