Results 41 to 50 of about 98,125 (260)

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Machine Learning Methods for Histopathological Image Analysis

Computational and Structural Biotechnology Journal, 2018
Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine learning techniques.
Daisuke Komura, Shumpei Ishikawa
doaj   +1 more source

Automated Detection Algorithm of Breast Masses in Three-Dimensional Ultrasound Images [PDF]

Healthcare Informatics Research, 2016
ObjectivesWe propose an automatic breast mass detection algorithm in three-dimensional (3D) ultrasound (US) images using the Hough transform technique.MethodsOne hundred twenty-five cropped images containing 68 benign and 60 malignant masses are acquired
Ji-Wook Jeong, Donghoon Yu, Sooyeul Lee, Jung Min Chang   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Computer-assisted Medical Decision-making System for Diagnosis of Urticaria

MDM Policy & Practice, 2016
Background: Urticaria is a common allergic disease that affects all age groups. Allergic disorders are diagnosed at allergy testing centers using skin tests. Though skin tests are the gold standard tests for allergy diagnosis, specialists are required to
Jabez J. Christopher BE, ME, Harichandran Khanna Nehemiah BE, ME, PhD, Kannan Arputharaj ME, PhD, George L. Moses MSc, PhD   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Asia-Pacific consensus on the use of artificial intelligence in colorectal cancer screening and surveillance

iGIE
Background and Aims: Artificial intelligence (AI)-assisted colonoscopy has been widely investigated for colorectal adenoma and cancer detection and characterization.
Frederick H. Koh, PhD, James W. Li, MD, Sunny H. Wong, DPhil, Jonathan Lee, MD, Sneha John, FRACP, Vui Heng Chong, MD, Kai-chun Wu, MD, Rashid Lui, FRCP, Simon S.M. Ng, MD, Thomas Y.T. Lam, PhD, Louis H.S. Lau, MBChB, Govind K. Makharia, MD, Murdani Abdullah, MD, Hasan Maulahela, MD, Nozomu Kobayashi, MD, Masau Sekiguchi, MD, Jeong-Sik Byeon, MD, Hyun-soo Kim, MD, Yeong Yeh Lee, MD, Han-Mo Chiu, MD, I-Chen Wu, MD, Somchai Leelakusolvong, MD, Prateek Sharma, MD, David Lieberman, MD, Joseph J.Y. Sung, MD   +24 more
doaj   +1 more source