Results 101 to 110 of about 12,810,150 (402)

Orientation in the diagnosis of intraocular neoplasia, through intraocular fine needle aspiration (IFNA) [PDF]

, 2018
IFNA is a safe diagnostic technique that allows diagnostic of neoplastic and inflammatory processes of the eye1. In cats melanoma is common in the eye, skin and oral cavity2. In the eyep, local infiltration to systemic metastases may occur2.
Alexandre, N., Cardoso, K., Guimarães, T., Laranjo, M.   +3 more
core  

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.

European Heart Journal, 2021
T. McDonagh, M. Metra, M. Adamo, R. S. Gardner, A. Baumbach, Michael Böhm, H. Burri, J. Butler, J. Čelutkienė, O. Chioncel, John G. Cleland, A. Coats, M. Crespo-Leiro, Dimitrios Farmakis, Martine Gilard, Stephane Heymans, Arno W. Hoes, T. Jaarsma, E. A. Jankowska, M. Lainščak, C. S. Lam, A. Lyon, J. J. McMurray, A. Mebazaa, Richard Mindham, Claudio Muneretto, Massimo Francesco Piepoli, Susanna Price, G. Rosano, F. Ruschitzka, Anne Kathrine Skibelund   +30 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Undifferentiated carcinoma of the liver with osteoclast-like giant cells: a case report and literature review

Infectious Agents and Cancer
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Osteoclast-like giant cells (OGCs) are relatively more common in pancreatic cancer, but extremely rare in HCC. Currently, there have been only a few reported cases of
Lixia Lu, Li Wang, Can Peng, Li Chen, Ximan He, Chenning Shao, Chunnian Wang, Rong Ge   +7 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts

Acta Neuropathologica Communications, 2019
The diagnosis and prognostication of glioblastoma (GBM) remain to be solely dependent on histopathological findings and few molecular markers, despite the clinical heterogeneity in this entity. To address this issue, we investigated the prognostic impact
Toru Umehara, Hideyuki Arita, Ema Yoshioka, Tomoko Shofuda, Daisuke Kanematsu, Manabu Kinoshita, Yoshinori Kodama, Masayuki Mano, Naoki Kagawa, Yasunori Fujimoto, Yoshiko Okita, Masahiro Nonaka, Kosuke Nakajo, Takehiro Uda, Naohiro Tsuyuguchi, Junya Fukai, Koji Fujita, Daisuke Sakamoto, Kanji Mori, Haruhiko Kishima, Yonehiro Kanemura   +20 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Adenosine stress myocardial perfusion imaging and myocardial work in evaluating INOCA

Scientific Reports
To assess myocardial functional abnormalities in ischemia with non-obstructive coronary arteries (INOCA) using adenosine stress myocardial contrast echocardiography (AS-MCE) combined with Myocardial Work (MW).
Xuemei Zhang, Shuixiu Dou, Feifei Zhang, Ping Lou, Jing Jin, Ying Zhao, Xin Zhao, Fengsheng Li, Yuhan Li   +8 more
doaj   +1 more source

Discrepancy of QF-PCR, CMA and karyotyping on a de novo case of mosaic isodicentric Y chromosomes

Molecular Cytogenetics, 2019
Background Isodicentric chromosomes are the most frequent structural aberrations of human Y chromosome, and usually present in mosaicism with a 45, X cell line.
Yuan Liu, Li Guo, Hanbiao Chen, Jian Lu, Jingjing Hu, Xianzheng Li, Xing Li, Ting Wang, Fengzhen Li, Aihua Yin   +9 more
doaj   +1 more source

Altered structure of the vestibular cortex in patients with vestibular migraine

Brain and Behavior, 2020
Introduction Previous voxel‐based morphometry (VBM) studies have revealed changes in brain structure in patients with vestibular migraine (VM); these findings have improved the present understanding of pathophysiology. Few other studies have assessed the
Xia Zhe, Jie Gao, Li Chen, Dongsheng Zhang, Min Tang, Xuejiao Yan, Fuxia Bai, Xin Zhang, Ze Zou, Weibo Chen, Xiaoyan Lei, Xiaoling Zhang   +11 more
doaj   +1 more source