Results 101 to 110 of about 6,560,036 (301)
Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity
Scientific Reports, 2017 To explore dendritic cells/tumor-derived endothelial cells (DC/EC) fusion cells are potent stimulators of T cells to impact tumor progression. ECs were isolated from mice hepatoma cell line (H22) Xenograft, and dendritic cells were isolated from bone ...
Yingying Huang +9 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Preimplantation Genetic Diagnosis
, 2004 Preimplantation genetic diagnosis (PGD) was introduced at the beginning of the 1990s as an alternative to prenatal diagnosis, to prevent termination of pregnancy in couples with a high risk for offspring affected by a sex-linked genetic disease.
Sermon, Karen; Van Steirteghem, Andre; Liebaers, Inge
core
, 2020 Introduction: This study is designed to test the hypothesis that a relationship exists between emotional reaction to diagnosis and the subsequent adherence to diet and exercise regimen, and to correlate the responses of subjects with factors like ...
Its, Diagnosis, Management, On
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Infection and Drug ResistanceXiao Lei,1– 3,* Liyuan Zhao,1– 3,* Ziwei Zhong,1– 3,* Haiyan Lin,1– 3 Zhiting Xie,1– 3 Yaping Guo,1– 3 Sufeng Zhang,1– 4 Chengsheng Zhang,1– 3 Tian Gong1– 31Center for Molecular Diagnosis and Precision Medicine, The First ...
Lei X +8 more
doaj
Aptamer Combined with Fluorescent Silica Nanoparticles for Detection of Hepatoma Cells
Nanoscale Research Letters, 2017 Purpose The purpose of this study is to develop a simple, effective method to label hepatoma cells with aptamers and then detect them using fluorescent silica nanoparticles (FSNPs).
Zixi Hu +12 more
doaj +1 more source
Leprosy Review, 1961 As a person declared to be suffering from leprosy unfortunately becomes a marked man in his community. One should not make a diagnosis of leprosy unless the signs are unequivocal. Leprosy presents a characteristic and easily recognizable picture in the advanced stages but in the early stages it may be greatly difficult.
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source