Results 161 to 170 of about 4,771,065 (318)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Cell-derived microvesicles in infective endocarditis: Role in diagnosis and potential for risk stratification at hospital admission [PDF]

, 2019
Milton Henriques Guimarães Júnior, Teresa Cristina Abreu Ferrari, Andréa Teixeira‐Carvalho, Marcela L. Moreira, Lorena Júnia de Souza Santos, Matheus Fernandes Costa-Silva, Rodrigo Coelho, Pedro Henrique Oliveira Murta Pinto, Tijmen Ris, Jonathas Teixeira Salles, Lívia Silva Araújo Passos, Maria Carmo Pereira Nunes   +11 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Artificial intelligence and psychiatric diagnosis: a warning to the mental health community. [PDF]

World Psychiatry
Frances A.
europepmc   +1 more source

Management of hypertension in pregnancy — prevention, diagnosis, treatment and long-term prognosis. A position statement of the Polish Society of Hypertension, Polish Cardiac Society and Polish Society of Gynaecologists and Obstetricians

, 2019
Aleksander Prejbisz, Piotr Dobrowolski, Przemysław Kosiński, Dorota Bomba‐Opoń, Marcin Adamczak, Monika Bekiesińska‐Figatowska, Jacek Kądziela, Anna Konopka, Katarzyna Kostka-Jeziorny, Ilona Kurnatowska, Bożena Leszczyńska‐Gorzelak, Mieczysław Litwin, Agnieszka Olszanecka, Michał Orczykowski, Elżbieta Poniedziałek‐Czajkowska, Małgorzata Sobieszczańska‐Małek, Katarzyna Stolarz‐Skrzypek, Ludwina Szczepaniak‐Chicheł, Anna Szyndler, Jacek Wolf, Mirosław Wielgoś, Piotr Hoffmań, Andrzej Januszewicz   +22 more
openalex   +2 more sources

Diagnosis of the Degree of Degradation of an Ecosystem: the Basis and Precondition of Ecological Restoration [PDF]

, 2003
Xiaojun Du, Gao Xianming, Ma Keping
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Drivers of Diagnostic Delay in Mitochondrial Disease: Missed Recognition of Canonical Features. [PDF]

JIMD Rep
Tinker RJ, Jacob N, Syed MG, Kelkar J, Donnelly C, Elsharkawi I, Ganesh J, Gelb BD, Pejaver V, Kozicz T, Morava E.   +10 more
europepmc   +1 more source

Editorial. Diagnosis, diagnosis, diagnosis: towards DSM-5 [PDF]

British Dental Journal, 2010
openaire   +1 more source