Results 191 to 200 of about 443,911 (293)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Diagnostic Performance of Multimodal Large Language Models for Central Venous Catheter Assessment Chest Radiographs in the Intensive Care Unit. [PDF]

Med Sci (Basel)
Theocharidou CC, Tsinaris Z, Karachristos C, Theocharidou A, Kourtidis M, Papadopoulou K, Peristeri AM, Astreinidis A, Simichanidou A, Giannaki C, Tzimou M, Kaimakamis E, Voutsas V, Soulountsi V, Lavrentieva A.   +14 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A two-stage workflow for vitiligo diagnosis: clinical characteristic classification and large language model (LLM)-based report generation. [PDF]

Front Immunol
He K, Xu T, Feng Y, Lu Y, Wang X, Jiang L, Guo S, He Y, Dai W, Zhang W, Zhang J, Lu H, Huang D, Li S.   +13 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Comprehensive benchmarking of deep learning architectures for multiclass histopathological classification of oral epithelial lesions. [PDF]

J Oral Biol Craniofac Res
Bharti A, Kashyap N, Kamboj M, Joshi K, Hooda S, Mishra D, Singh H, Pal D.   +7 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Advancing medical imaging diagnostics using deep learning for accurate spinal disorder classification. [PDF]

J Educ Health Promot
Chandran R, Rengeswaran B, Ramasamy L.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Metaheuristic hyperparameter optimization of deep neural networks for demographic-aware autism spectrum disorder classification. [PDF]

Sci Rep
Aly M, Alotaibi NM.
europepmc   +1 more source