Results 41 to 50 of about 239,720 (262)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Availability of technology for managing cancer patients in the Southeast European (SEE) region

Clinical and Translational Radiation Oncology, 2022
Background: The Southeast European (SEE) region of 10 countries and about 43 million people differs from Western Europe in that most SEE countries lack active cancer registries and have fewer diagnostic imaging devices and radiotherapy (RT) units.
Manjit Dosanjh, Mimoza Ristova, Vesna Gershan, Petya Georgieva, Marijana Balin Kovacevic, Ledio Bregu, Irma Coralic, Tamara Djurovic, Deyana Dosieva, Yiota Foka, Ana Fröbe, Konstantinos Hatziioannou, Costas J. Hourdakis, Yllka Kabashi, Dimitar Kalev, Ilir Kurtishi, Leandar Litov, Beqir Mezelxhiu, Svetlana Nestoroska Madjunarova, Gordana Nikolova, Damijan Skrk, Velda Smajlbegovic, Snezana Smichkoska, Igor Stojkovski, Primož Strojan, Zdravka Tecic, Dušanka Tešanović, Vladimir Todorovic, Zdravka Valerianova   +28 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

How and why do Australians obtain blood pressure devices for use at home? A mixed-methods study revealing health literacy responsive ways to support this self-management behaviour

Health Literacy and Communication Open
Background Adequate health literacy is integral to support self-management behaviours, including home blood pressure (BP) monitoring, which is recommended for hypertension management.
Eleanor Clapham, Samuel Carmichael, Kaylee Slater, Aletta E. Schutte, John Stevens, Mark R. Nelson, Markus Schlaich, Rachel E. Climie, Ross T. Tsuyuki, George Stergiou, Norm RC Campbell, Dean S. Picone, Niamh Chapman   +12 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

BASIC REQUIREMENTS AND PRINCIPLES OF CREATION ONBOARD DIAGNOSTIC SYSTEMS OF LOCOMOTIVES

Nauka ta progres transportu, 2014
Purpose. Justification of the basic principles of construction on-board diagnostic systems locomotive and choose from high-performance and reliable interface for the exchange of information on-board diagnostic systems. Methodology.
YE. B. Bodnar
doaj  

Validation of a Patient-Specific Musculoskeletal Model for Lumbar Load Estimation Generated by an Automated Pipeline From Whole Body CT

Frontiers in Bioengineering and Biotechnology, 2022
Background: Chronic back pain is a major health problem worldwide. Although its causes can be diverse, biomechanical factors leading to spinal degeneration are considered a central issue.
Tanja Lerchl, Tanja Lerchl, Malek El Husseini, Amirhossein Bayat, Amirhossein Bayat, Anjany Sekuboyina, Luis Hermann, Kati Nispel, Kati Nispel, Thomas Baum, Maximilian T. Löffler, Maximilian T. Löffler, Veit Senner, Jan S. Kirschke   +13 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Comparing visual and automated urine dipstick analysis in a general practice population

Scandinavian Journal of Primary Health Care
Introduction Urinary symptoms constitute the primary reason for female patients to consult their general practitioner. The urinary dipstick test serves as a cornerstone for diagnosing urinary tract infections (UTIs), yet traditional visual interpretation
S. M. L. Cox, P. Hoitinga, G. J. Oudhuis, R. M. Hopstaken, P. H. M. Savelkoul, J. W. L. Cals, E. G. P. M. de Bont   +6 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source