Results 171 to 180 of about 18,071 (216)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis: A modelling study. [PDF]

PLoS Med
Horton KC, Richards AS, Schwalb A, Houben RMGJ.   +3 more
europepmc   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Development of a national consensus guideline for termination of resuscitation in the out-of-hospital environment. [PDF]

Br Paramed J
Smyth MA, Brown TP, Fothergill R, Griffiths F, Lall R, Long J, Petrou S, Siriwardena AN, Slowther AM, Bettely L, Eli K, Gardiner G, Huxley C, Khan K, Michelet F, Perkins GD.   +15 more
europepmc   +1 more source

Commentary: Should we worry about climate worry? Understanding and promoting youth resilience and pro‐environmental engagement: a commentary on Park et al. (2026)

Child and Adolescent Mental Health, EarlyView.
Understanding the mental health impact of climate change is of paramount importance to promoting youth resilience and pro‐environmental engagement. Here, we reflect on the study of Park et al. (Child and Adolescent Mental Health, 2026) on the prevalence and mental health correlates of climate worry in young adolescents.
Stathis Grapsas, Atheer Massarwe
wiley   +1 more source

Endoscopic Diagnostics for IgG4-Related Pancreatobiliary Diseases: Current Modalities and Clinical Perspectives. [PDF]

Diagnostics (Basel)
Naitoh I, Yoshida M, Nakazawa T.
europepmc   +1 more source

Sustained Clinical Improvement in Birch Pollen Allergy After Two Pre‐Seasonal Short Courses of Allergen‐Specific Immunotherapy: A Long‐Term Open‐Label Extension Study

Clinical &Experimental Allergy, EarlyView.
3 years follow‐up study to a DBPC dose‐finding trial investigating subcutaneous immunotherapy with T502 in birch‐pollen induced allergic rhinoconjunctivitis. 154 birch‐pollen allergic adults received short‐course treatment of 10,000 mTU/mL of T502 for 2 years and were observed during the next season without treatment.
Ralph Mösges, Friederike Hüffmeier, Ludger Klimek, Oliver Pfaar, Christian Neuhof, Anna Rybachuk, Cengizhan Acikel, Hacer Sahin, Silke Allekotte, Sandra del Pozo, José Luis Subiza, Miguel Casanovas, Mandy Cuevas, Laura Day, Lea Radtke, Esther Raskopf   +15 more
wiley   +1 more source

Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease. [PDF]

Mol Cancer
Fidelle M, Chen H, Montégut L, Boulate D, Abdayem P, Martineau M, Kuznetsova T, van der Aalst CM, de Koning HJ, Zitvogel L, Kroemer G.   +10 more
europepmc   +1 more source

Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study

Clinical &Experimental Allergy, EarlyView.
Global Asthma Network Phase I surveyed children, adolescents, and adults worldwide to assess the prevalence of asthma, rhinoconjunctivitis, and eczema. Human Development Index (HDI) and Gini inequality index (GinI) were important explanatory factors for prevalence variability of these conditions, with hotspots in areas with high HDI and high GinI ...
Luis García‐Marcos, Chen‐Yuan Chiang, M. Innes Asher, Guy B. Marks, Asma El Sony, Refiloe Masekela, Karen Bissell, Eamon Ellwood, Philippa Ellwood, Neil Pearce, David P. Strachan, A. Elena Martínez‐Torres, Manuel Sánchez‐Solís, Kevin Mortimer, Eva Morales, The Global Asthma Network Phase I Study Group   +15 more
wiley   +1 more source

Development of solid-state fluorescence lifetime standards for clinical applications using dyed epoxy resins. [PDF]

J Biomed Opt
Angelone D, Hughes K, Yavari H, Garduño Gómez SE, Wilson BC, Andersson-Engels S, Komolibus K, Konugolu Venkata Sekar S.   +7 more
europepmc   +1 more source