Results 81 to 90 of about 46,453 (252)

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

A cDNA Microarray Gene Expression Data Classifier for Clinical Diagnostics Based on Graph Theory [PDF]

, 2011
Despite great advances in discovering cancer molecular profiles, the proper application of microarray technology to routine clinical diagnostics is still a challenge. Current practices in the classification of microarrays' data show two main limitations:
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria   +2 more
core   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Estudio genético en pacientes jóvenes con enfermedad renal crónica avanzada de etiología no filiada. Diseño del estudio GENSEN

Nefrología
Resumen: Introducción: La enfermedad renal crónica (ERC) de etiología no filiada es una de las principales causas de tratamiento sustitutivo renal en nuestro medio. Estudios previos en otros territorios sugieren que las enfermedades hereditarias podrían
Miquel Blasco, Borja Quiroga, José M. García-Aznar, Roser Torra, Alberto Ortiz, Patricia de Sequera   +5 more
doaj   +1 more source

The earliest iron-producing communities in the Lower Congo region of Central Africa : new insights from the Bu, Kindu and Mantsetsi sites [PDF]

, 2019
In 2015 the KongoKing research project team excavated the Bu, Kindu and Mantsetsi sites situated in the Kongo-Central Province of the Democratic Republic of Congo (DRC). All are part of the Kay Ladio Group.
Beeckman, Hans, Bostoen, Koen, Clist, Bernard-Olivier, Hubau, Wannes, Tshibamba Mukendi, John   +4 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Post-cholecystectomy biliary leakage mimicking a neoplastic lesion: contribution of cholangioscopy in diagnosis and endoscopic treatment

Endoscopy International Open, 2023
Pierre Mayer, Pierre-Yves Christmann, Aina Venkatasamy, Georges Uhl, Sebastian Vuola, Lucile Heroin, François Habersetzer   +6 more
doaj   +1 more source

Medication Non-Adherence in Anxiety and Depression

Journal of Islamic International Medical College, 2021
Objective :To find out the frequency of non-adherence in patients with anxiety and depression, receiving treatment in teaching hospitals. Study Design: A cross-sectional descriptive study Place and Duration of Study: The study was conducted at Pakistan ...
Masood Khokhar, Shafaq Masood, Ather Muneer, Uzzama Waheed, Farwa Aftab, Irum Bibi
doaj  

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

The Spectral Energy Distribution of Fermi bright blazars [PDF]

, 2009
(Abridged) We have conducted a detailed investigation of the broad-band spectral properties of the \gamma-ray selected blazars of the Fermi LAT Bright AGN Sample (LBAS).
A. A. Abdo, A. A. Arkharov, A. A. Moiseev, A. Berdyugin, A. Brez, A. Chekhtman, A. de Angelis, A. Falcone, A. Giuliani, A. K. Harding, A. Makeev, A. Morselli, A. P. Marscher, A. P. Waite, A. Reimer, A. S. Johnson, A. Sadun, A. Sander, A. Sellerholm, A. Tramacere, A. W. Borgland, A. Y. Rodriguez, Abdo, Abdo, Abdo, Abdo, Abdo, Acciari, Acciari, Aharonian, Ajello, Ajello, Albert, Albert, Albert, Angelakis, Atwood, B. Berenji, B. Giebels, B. L. Winer, B. Lott, B. M. Baughman, Baars, Bessel, Blandford, C. Cecchi, C. D. Dermer, C. Farnier, C. Favuzzi, C. Gronwall, C. Meurer, C. Monte, C. Pagani, C. Pittori, C. Raiteri, C. Sgrò, Colafrancesco, Costamante, D. A. Smith, D. Bastieri, D. Burrows, D. Carosati, D. Dultzin, D. Dumora, D. F. Torres, D. Gasparrini, D. Hadasch, D. Hiriart, D. Horan, D. J. Suson, D. J. Thompson, D. Paneque, D. Parent, D. Sanchez, Dermer, Donnarumma, E. A. Hoversten, E. Angelakis, E. Benitez, E. Bonamente, E. Cavazzuti, E. Charles, E. D. Bloom, E. do Couto e Silva, E. Forné, E. Hays, E. J. Siskind, E. Koptelova, E. Lindfors, E. N. Kopatskaya, E. Nuss, E. Orlando, Errando, F. D'ammando, F. de Palma, F. Gargano, F. Giordano, F. Longo, F. Loparco, F. Marshall, F. Piron, F. Rahoui, F. Ryde, F. Verrecchia, Fuhrmann, G. A. Caliandro, G. Barbiellini, G. Chincarini, G. Godfrey, G. Jóhannesson, G. Kimeridze, G. M. Madejski, G. Spandre, G. Stratta, G. Tosti, G. V. Zhekanis, Gehrels, Ghisellini, Giommi, Giommi, Giommi, H. D. Aller, H. F.-W. Sadrozinski, H. Katagiri, H. Tajima, H. Takahashi, Hartman, Healey, Healey, I. A. Grenier, I. Agudo, I. Donnarumma, I. Nestoras, I. V. Moskalenko, J. A. Ros, J. A. Zensus, J. B. Thayer, J. Ballet, J. Bregeon, J. Chiang, J. Cohen-Tanugi, J. Conrad, J. D. Scargle, J. E. Grove, J. E. McEnery, J. F. Ormes, J. G. Thayer, J. H. Panetta, J. Heidt, J. Kataoka, J. Kennea, J. Knödlseder, J. L. Gómez, J. L. Richards, J. Lande, J. M. Casandjian, J. Osborne, J. P. Norris, J.-L. Starck, K. Bechtol, K. Nilsson, K. Page, K. S. Wood, Korolkov, Kovalev, Kovalev, Kovalev, Kubo, L. A. Sigua, L. Baldini, L. Calzoletti, L. Costamante, L. Fuhrmann, L. Guillemot, L. Latronico, L. O. Takalo, L. Pacciani, L. R. Cominsky, L. S. Rochester, L. Tibaldo, Lagage, Lister, M. A. Gurwell, M. Ackermann, M. Ajello, M. Axelsson, M. Boettcher, M. Brigida, M. Capalbi, M. E. Monzani, M. F. Aller, M. Frailis, M. Hayashida, M. Kadler, M. Kerr, M. Kuss, M. L. Kocian, M. N. Lovellette, M. N. Mazziotta, M. Ozaki, M. Pasanen, M. Pepe, M. Perri, M. Pesce-Rollins, M. Razzano, M. Roth, M. S. Jackson, M. S. Shaw, M. S. Strickman, M. Stevenson, M. Villata, M. Ziegler, Marchã, Mazziotta, Monet, Moretti, N. A. Nizhelsky, N. Gehrels, N. Giglietto, N. Kawai, N. Omodei, N. Vilchez, O. M. Kurtanidze, O. Reimer, Ott, P. A. Caraveo, P. Bruel, P. D. Smith, P. F. Michelson, P. Fortin, P. Fusco, P. Giommi, P. L. Nolan, P. Leto, P. Lubrano, P. M. Saz Parkinson, P. Marchegiani, P. Padovani, P. Roustazadeh, P. S. Drell, P. Spinelli, P. Wang, Padovani, Padovani, Poole, R. A. Cameron, R. Bellazzini, R. Claus, R. D. Blandford, R. Deitrick, R. Dubois, R. E. Hughes, R. Itoh, R. Ojha, R. Rando, R. W. Romani, S. Buson, S. Chaty, S. Ciprini, S. Colafrancesco, S. Cutini, S. E. Healey, S. Funk, S. G. Jorstad, S. Germani, S. Guiriec, S. J. Fegan, S. Murgia, S. Piranomonte, S. Puccetti, S. Rainò, S. Ritz, S. W. Digel, Schlegel, Sikora, T. A. Porter, T. Glanzman, T. H. Burnett, T. Kamae, T. L. Usher, T. Mizuno, T. Ohsugi, T. Reposeur, T. S. Konstantinova, T. Takahashi, T. Tanaka, T. Ylinen, Teshima, Tramacere, U. Bach, V. D'Elia, V. M. Larionov, V. Pavlidou, V. Pelassa, V. Vasileiou, V. Vitale, Vercellone, W. B. Focke, W. Max-Moerbeck, W. McConville, W. Mitthumsiri, W. N. Johnson, W. P. Chen, Weekes, Y. Fukazawa, Y. Hanabata, Y. Uchiyama, Y. Y. Kovalev, Yu. A. Kovalev, Ö. Çelik   +309 more
core   +4 more sources