Results 141 to 150 of about 7,713,923 (357)

Diagnostic Peritoneal Lavage : an obituary? [PDF]

open access: yes, 2006
Diagnostic peritoneal lavage (DPL) has been used as a diagnostic procedure in patients with blunt abdominal trauma for almost a century. Its accuracy and reliability are high.
Cassar, Kevin
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Production Of Recombinant Urease For Screening Of Helicobacter Pylori Infection [PDF]

open access: yes, 2014
Helicobacter pylori establishes infection inside human stomach lining and causing duodenal diseases, such as peptic ulcer and potentially into gastric cancer. The invasive diagnostic methods require unpleasant endoscopic procedure for H. pylori detection.
Mohamad, Che Wan Sharifah Robiah
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

The role and importance of screening procedures in early diagnostics of hearing impairment [PDF]

open access: bronze, 2012
Vranješ Dalibor   +7 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Evaluation of diagnostic test procedures for SARS‐CoV‐2 using latent class models [PDF]

open access: hybrid, 2022
Jacob Stærk‐Østergaard   +6 more
openalex   +1 more source

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