IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Decadal Changes in Institutional Diagnostic Reference Levels for X-Ray Angiography: A Retrospective Comparative Study. [PDF]
Antonakos I +10 more
europepmc +1 more source
Methods of checking the observance of diagnostic reference levels in the field of radiodiagnostics
Methods of Checking the Observance of Diagnostic Reference Levels in the Field of Radio diagnostics Although there is a simultaneous development of diagnostic and therapeutic methods, perfection of instrumentation and means for personnel and patient ...
KROUPOVÁ, Helena
core
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Diagnostic Reference Levels for Dental Cone Beam Computed Tomography: A Critical Appraisal of Global Progress and Remaining Gaps. [PDF]
Aminaei D, Ozlati A, Pita de Melo D.
europepmc +1 more source
Outstanding Business Reference Sources: The 2008 Selection of Recent Titles
A selection of business reference sources for ...
BRASS Business Reference Sources Committee
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara +3 more
wiley +1 more source
Establishment of National Diagnostic Reference Levels for Coronary Angiography and Interventional Procedures. [PDF]
Kim D +6 more
europepmc +1 more source
Diagnostic Reference Levels: A Review
openaire +1 more source

