Results 41 to 50 of about 6,501,442 (268)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Sutureless Cataract Surgery: Principles and Steps

Community Eye Health Journal, 2003
Introduction. Cataracts cause about 50% of world blindness. There is little likelihood of effective prevention becoming available in the next few years and so the only treatment will remain surgical. For many of the other major causes of world blindness,
John Sandford-Smith
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Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations

Insights into Imaging, 2021
Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris.
Pietro Valerio Foti, Mario Travali, Renato Farina, Stefano Palmucci, Corrado Spatola, Luigi Raffaele, Vincenzo Salamone, Rosario Caltabiano, Giuseppe Broggi, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Paolo Vigneri, Teresio Avitabile, Giovani Carlo Ettorre, Antonio Basile   +16 more
doaj   +1 more source

Neuro-ophthalmological manifestations of tuberous sclerosis: current perspectives

, 2019
Tuberous sclerosis complex (TSC) is a complex, multi-system disorder with a well-described underlying genetic etiology. While retinal findings are common in TSC and important in establishing the diagnosis, TSC also has many potential neuro-ophthalmology ...
Lo Chan, Ka, Wan, Michael J, Jastrzembski, Benjamin G, Ali, Asim   +3 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Diagnostic Accuracy of Ultrasound in Detection of Traumatic Lens Dislocation

Emergency, 2014
Introduction: Traumatic eye injuries (TEI) involved about 3% of cases referred to the emergency departments of developing countries. Lens dislocation is one of the critical cases of ophthalmic emergencies.
Seyed Hossein Ojaghi Haghighi, Hamid Reza Morteza Begi, Raana Sorkhabi, Mohammad Kazem Tarzamani, Golshan Kamali Zonouz, Akram Mikaeilpour, Farzad Rahmani   +6 more
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Case Report of Schnyder Corneal Dystrophy—A Rare Lipid Metabolic Disorder of the Cornea

Life
Background: Schnyder corneal dystrophy (SCD) is a rare autosomal dominant disorder characterized by bilateral corneal opacification due to abnormal cholesterol and phospholipid deposition.
Nina Stoyanova, Abdulrahman Imran, Zain Ul Hassan, Krasimir Kraev, Yordanka Basheva-Kraeva, Maria Kraeva, Petar Uchikov, Plamena Novakova, Veselin Vasilev, Ivaylo Minev, Bozhidar Hristov, Desislava Koleva-Georgieva, Petko Petrov, Luboslav Dimov, Svetlan Dermendzhiev, Marin Atanassov   +15 more
doaj   +1 more source

Comparison of central corneal edema and visual recovery between liquefaction and conventional phacoemulsification in soft cataracts Comparação do edema de córnea central e da recuperação visual após facoemulsificação por liquefação e convencional em cataratas moles

Revista Brasileira de Oftalmologia, 2009
PURPOSE: The aim of the present study is to assess central corneal edema and visual recovery after cataract surgery performed according to two technologies: conventional ultrasonic and liquefaction (Aqualase®). METHODS:This is a prospective contralateral
Celso Takashi Nakano, Wilson Takashi Hida, Newton Kara-Jose Junior, Antonio Francisco Pimenta Motta, Alexandre Reis, Mauricio Pamplona, Reinaldo Fujita, Iris Yamane, Ricardo Holzchuh, Amaryllis Avakian   +9 more
doaj   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Axenfeld-Rieger syndrome

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Axenfeld-Rieger syndrome is a rare congenital disease that has an autosomal-dominant inheritance pattern. The ophthalmic disorder with the dysgenesis of the anterior segment is what defines the disease. This study presents the case of a 9-month-old still-
Kenia Verdecia-Jacobo, Enaydys Gómez-de-Armas, Katiria Sales-Armas   +2 more
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