Results 191 to 200 of about 9,461,475 (306)

Choice of Diagnostic Tests

Journal of the Royal College of Physicians of London, 1975
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Predictive Accuracy of Chemotherapy Toxicity Tools in Older Adults with Cancer: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis. [PDF]

Cancers (Basel)
Aguirre-Milachay E, Valladares-Garrido MJ, Chapoñan-Agip NV, Cahuapaza-Gutierrez NL, Torres-Zegarra BC, Diaz-Torres M, León-Figueroa DA, Runzer-Colmenares FM.   +7 more
europepmc   +1 more source

Corrigendum to "Biofire FilmArray Meningitis/Encephalitis panel for the aetiological diagnosis of central nervous system infections: a systematic review and diagnostic test accuracy meta-analysis". [PDF]

EClinicalMedicine
Trujillo-Gomez J, Tsokani S, Arango-Ferreira C, Atehortua-Muñoz S, Jimenez-Villegas MJ, Serrano-Tabares C, Veroniki AA, Florez ID.   +7 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Diagnostic Test Analysis of Intraoperative Direct Sonication in Detecting Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Kondo S, Yamamoto N, Saitsu A, Ishikane M, Hirao Y, Corpuz A, Someko H.   +6 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Molecular diagnostic testing [PDF]

Genetics in Medicine, 2015
openaire   +2 more sources

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Diagnostic accuracy of imaging modalities for primary small-bowel tumors: a systematic review and diagnostic test accuracy meta-analysis. [PDF]

Front Oncol
Xia Q, Li Q, Ding C, Wang J.
europepmc   +1 more source