Results 71 to 80 of about 17,010,700 (403)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Rodent Diagnostic Testing

Journal of Exotic Pet Medicine, 2008
Clinical medicine is an important part of scientific medicine that is all too often neglected when treating rodents and small mammal pets. As with more traditional pets, a progressive diagnostic regimen should include a thorough history, clinical signs, physical examination, and laboratory findings.
openaire   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Comparative efficacy of conventional diagnostic methods and evaluation of polymerase chain reaction for the diagnosis of bovine brucellosis [PDF]

Veterinary World, 2010
The comparative efficacy of Rose Bengal Plate Test (RBPT) and Milk Ring test (MRT) was calculated in terms of sensitivity and specificity for the diagnosis of bovine brucellosis in cows (Group A) and buffaloes (Group B) from Lahore and Okara districts of
Raheela Akhtar, Prof. Zafar Iqbal Chaudhry, Prof. A. R Shakoori, Mansoor ud Din Ahmad and Asim Aslam   +3 more
doaj  

The Brier score does not evaluate the clinical utility of diagnostic tests or prediction models

Diagnostic and Prognostic Research, 2017
BackgroundA variety of statistics have been proposed as tools to help investigators assess the value of diagnostic tests or prediction models. The Brier score has been recommended on the grounds that it is a proper scoring rule that is affected by both ...
M. Assel, D. Sjoberg, A. Vickers
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Reliable and accurate diagnostics from highly multiplexed sequencing assays [PDF]

, 2020
Scalable, inexpensive, and secure testing for SARS-CoV-2 infection is crucial for control of the novel coronavirus pandemic. Recently developed highly multiplexed sequencing assays (HMSAs) that rely on high-throughput sequencing can, in principle, meet ...
Bloom, Joshua S., Booeshaghi, A. Sina, Cooper, Aaron R., Gehring, Jase, Kosuri, Sriram, Lubock, Nathan B., Luebbert, Laura, Pachter, Lior, Simpkins, Scott W.   +8 more
core  

Neurovisual training (TRIGRAM) in young patients with visual-perceptive dyslexia [PDF]

, 2017
Dyslexia is a language-based learning disability. Although this condition is characterized by anatomical malformation of the brain, it seems that the typical reading pattern of dyslexic may be also related to more complex sensory deficits.
CARLESIMO, Sandra Cinzia, Marchegiani, Chiara, MIGLIORINI, Raffaele, PACELLA, Elena, PACELLA, FERNANDA, SEGNALINI, Alessandro, TURCHETTI, PAOLO   +6 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Diagnostic tests for chancroid [PDF]

Sexually Transmitted Infections, 2000
The identification of the causative agent of chancroid, Haemophilus ducreyi , was first reported in 1889 by August Ducrey, as a short streptobacillary rod with rounded ends, following experiments in which he autoinoculated patients' forearms with pus from their genital ulcers.1 Bezancon et al subsequently inoculated the forearms of human volunteers ...
openaire   +2 more sources