Results 121 to 130 of about 4,142,479 (322)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Materials Today AdvancesDeveloping idea red phosphors with high quantum efficiency and excellent fluorescent thermal stability has special significance for both lighting and display devices but is still challenging.
Rong-Rong Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The Plan as Eidos: Bramante’s Half-Drawing and Durand’s Marche
RevistArquis, 2014 By confronting Bramante’s plan for St Peter Basilica (1503) with Durand’s “Method of Composition” - summarized in his Marche plate (1802) - a modern conceptualisation of the plan unfolds which can be explained through the philosophical notion of eidos ...
Alejandra Celedón
doaj
HOW VISIO 2003 CAN INFLUENCE INFORMATION TECHNOLOGY–CREATING UML MODELS [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2005 Developing an overall architecture and design before you begin to write code helps you produce asoftware system that meets requirements and is easier to develop and maintain in the long run.
Adrian LUPASC
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The Biosphere, the Semiosphere, the Umwelt, and the Niche
SignataIf we assume that a semiotic theory is composed of two interacting faces—i.e. a conceptual face and a topological face—, the confrontation between them becomes an instrument of validation, falsification, control, and advancement of such a theory.
Jacques Fontanille
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source