Results 221 to 230 of about 1,765,796 (262)

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The role of intermediary representations in solving lever balance problems with different target representations and problem complexities. [PDF]

Front Psychol
Xie C, Ye L, Chen J, Hong W, Fang Z, Guan F, Yao J, Xiong J, Xiao Y, Liu T.   +9 more
europepmc   +1 more source

Network Pharmacology and Experimental Evidence Indicate That Dihydrochelerythrine from <i>Toddalia asiatica</i> Ameliorates Pathological Features of Knee Osteoarthritis in Rats and Is Associated with PI3K/AKT Signaling. [PDF]

J Inflamm Res
Liu Y, Zhang Y, Zha Q, Yang X, Tian Y, Xia K, Zheng S.   +6 more
europepmc   +1 more source

Corrigendum: Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing. [PDF]

Genome Res
Zhang S, Wang Y, Jia L, Wen X, Du Z, Wang C, Hao Y, Yu D, Zhou L, Chen N, Chen J, Chen H, Zhang H, Celik I, Gülsoy G, Luo J, Qin B, Cui X, Liu Z, Zhang S, Esteban MA, Ay F, Xu W, Chen R, Li W, Hoffman AR, Hu JF, Cui J.   +27 more
europepmc   +1 more source

BIOCARD framework: integrating fecal bile acids, lipids, and metabolites to assess response to a cardiovascular health intervention. [PDF]

Gut Microbes
Zhang H, Chen L, Xu R, Jung H, Gao S, Khalsa AS, Bailey MT, Kelleher KJ, Loman BR, Spees CK, Zhu J.   +10 more
europepmc   +1 more source