Results 31 to 40 of about 5,477 (237)

齿轮类零件参数化设计系统的研究与开发

open access: yesJixie chuandong, 2009
Realizes automation which the gear class components design calculation and draws a chart, proposed take the parametrization design concept as the basis, uses which in AutoCAD inlays Visual LISP language and The DCL dialog box design language, realized ...
王鸿钧, 苏艳萍
doaj  

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

open access: yesAdvanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng   +8 more
wiley   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

open access: yesAdvanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv   +12 more
wiley   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu   +6 more
wiley   +1 more source

基于Visual Lisp机械零件图形尺寸参数化标注设计

open access: yesJixie chuandong, 2008
Based on Visual Lisp in the AutoCAD,dialog box type mark system of size tolerance,shape and position tolerance and roughness is developed,automatic mark of the tolerance and roughness is realized.A kind of simple mark method of the tolerance and ...
苏艳萍, 王鸿钧
doaj  

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

open access: yesAdvanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu   +10 more
wiley   +1 more source

基于Visual LISP的凸轮参数化设计

open access: yesJixie chuandong, 2012
The parametric drawing program of cam is discussed based on Visual lisp in AutoCAD.Cam parameters input using dialog box,modular design of rise and return profile curve and cam drawing automatic generation are developed.It provides an effective method ...
孟建, 刘猛
doaj  

CrossMatAgent: AI‐Assisted Design of Manufacturable Metamaterial Patterns via Multi‐Agent Generative Framework

open access: yesAdvanced Intelligent Discovery, EarlyView.
CrossMatAgent is a multi‐agent framework that combines large language models and diffusion‐based generative AI to automate metamaterial design. By coordinating task‐specific agents—such as describer, architect, and builder—it transforms user‐provided image prompts into high‐fidelity, printable lattice patterns.
Jie Tian   +12 more
wiley   +1 more source

Vehicle End Connection Installment Relative Position Simulating Platform Based on ADAMS/rail Redevelope

open access: yes机车电传动, 2011
In order to simulate the relative position of adjacent vehicle end connection installment under different line conditions, a software-platform based on ADAMS/rail was developed.
马鹏, 付茂海, 向阳, 王小中
doaj  

Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook

open access: yesAdvanced Intelligent Discovery, EarlyView.
Large language models (LLMs) are reshaping materials science. Acting as Oracle, Surrogate, Quant, and Arbiter, they now extract knowledge, predict properties, gauge risk, and steer decisions within a traceable loop. Overcoming data heterogeneity, hallucinations, and poor interpretability demands domain‐adapted models, cross‐modal data standards, and ...
Jinglan Zhang   +4 more
wiley   +1 more source

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