Results 231 to 240 of about 187,159 (331)

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

open access: yesInterdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen   +12 more
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

open access: yesInterdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi   +6 more
wiley   +1 more source

Evaluating Youth Participatory Action Research in the Americas: Comparative Insights on Empowerment, Methodologies, and Social Change

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Introduction Youth Participatory Action Research (YPAR) positions adolescents as co‐researchers to investigate and address social issues affecting their lives. While YPAR has gained global prominence, comparative research examining how it is conceptualized and practiced across regional contexts remains limited.
John Diaz   +5 more
wiley   +1 more source

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