Results 171 to 180 of about 33,047 (316)

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

open access: yesExperimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber   +10 more
wiley   +1 more source

Ageing exacerbates the adverse effects of respiratory muscle fatigue on vascular function, locomotor muscle fatigue and exercise performance in males

open access: yesExperimental Physiology, EarlyView.
Abstract This study investigated the effect of respiratory muscle fatigue on cardiovascular function, locomotor muscle fatigue and exercise performance in young and master athletes, a model of successful ageing. Ten young male (YA, 27.4 ± 4.4 years) and 11 male master endurance athletes (MA, 65.0 ± 5.1 years) performed, on separate days, two constant ...
Valentin Mons   +4 more
wiley   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

open access: yesExperimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer   +11 more
wiley   +1 more source

Endobronchial valve treatment improves diaphragm function in severe emphysema patients. [PDF]

open access: yesERJ Open Res
Ter Haar EAMD   +5 more
europepmc   +1 more source

Maximal strength and voluntary activation of adductor pollicis after a single session of acute intermittent hypercapnia or acute intermittent hypoxia

open access: yesExperimental Physiology, EarlyView.
Abstract Acute intermittent hypoxia (AIH) can increase maximal strength of limb muscles in people with incomplete spinal cord injury (SCI), but it is mostly untested in people without SCI. Acute intermittent hypercapnia (AIC) may engage similar respiratory circuits to AIH, but the effects of AIC on human limb motor output are unknown.
Anandit J. Mathew   +5 more
wiley   +1 more source

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