Results 191 to 200 of about 33,047 (316)

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury

open access: yesArthritis &Rheumatology, Volume 77, Issue 10, Page 1421-1432, October 2025.
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava   +9 more
wiley   +1 more source

Acute Effects of Caffeine and Taurine Co‐Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat

open access: yesEuropean Journal of Sport Science, Volume 25, Issue 10, October 2025.
ABSTRACT Caffeine and taurine are commonly co‐ingested pre‐exercise but elicit different thermoregulatory responses; however, their combined effect on thermoregulation is unknown. Therefore, we evaluated the effects of oral caffeine and taurine co‐ingestion on time to exhaustion (TTE) and thermoregulatory responses to cycling in the heat at the gas ...
James Aggett   +8 more
wiley   +1 more source

Impact of Beam‐Column Joint Modeling Uncertainties on the Seismic Response of Low‐Rise RC Frames

open access: yesEarthquake Engineering &Structural Dynamics, Volume 54, Issue 12, Page 3224-3243, 10 October 2025.
ABSTRACT Incremental recordwise Latin hypercube sampling (iLHS) and multiple stripe analysis (MSA) are employed to evaluate the seismic performance of low‐rise RC moment‐resisting frames subjected to uncertainties of both the values of the model parameters and the model type itself.
Medhat Elmorsy, Dimitrios Vamvatsikos
wiley   +1 more source

Assessing inspiratory drive and effort in critically ill patients at the bedside. [PDF]

open access: yesCrit Care
Tonelli R   +27 more
europepmc   +1 more source

Immunoproteasome Inhibition Positively Impacts the Gut‐Muscle Axis in Duchenne Muscular Dystrophy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Duchenne Muscular Dystrophy (DMD) features immune‐muscle crosstalk, where muscle fibre degeneration enhances pro‐inflammatory macrophage infiltration, worsening inflammation and impairing regeneration. Methods We investigated the impact of immunoproteasome (IP) inhibition on the gut‐muscle axis in mdx mice, a well‐established model ...
Andrea Farini   +17 more
wiley   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

open access: yesMedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan   +6 more
wiley   +1 more source

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