Results 31 to 40 of about 67,649 (311)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers

Molecules, 2015
The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a ...
Ashling Holland, Michael Henry, Paula Meleady, Claudia K. Winkler, Mirjam Krautwald, Heinrich Brinkmeier, Kay Ohlendieck   +6 more
doaj   +1 more source

Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
Forcina, Laura, Musaro', Antonio, Nicoletti, Carmine, Pelosi, Laura, Scicchitano, Bianca Maria   +4 more
core   +3 more sources

Autophagy-associated atrophy and metabolic remodeling of the mouse diaphragm after short-term intermittent hypoxia. [PDF]

PLoS ONE, 2015
Short-term intermittent hypoxia (IH) is common in patients with acute respiratory disorders. Although prolonged exposure to hypoxia induces atrophy and increased fatigability of skeletal muscle, the response to short-term IH is less well known.
Christian Giordano, Christian Lemaire, Tong Li, R John Kimoff, Basil J Petrof   +4 more
doaj   +1 more source

Exercise-induced respiratory muscle work: Effects on blood flow, fatigue and performance [PDF]

, 2008
This is the post print version of this article. The official published version can be obtained from the link below.In healthy subjects, heavy intensity endurance exercise places substantial demands on the respiratory muscles as breathing frequency ...
C.A. Harms, D.E. O’Donnell, J.A. Dempsey, J.D. Miller, J.D. Miller, J.M. Hill, K.N. Stark-Leyva, L.M. Romer, M. Simon   +8 more
core   +1 more source

Manual evaluation of the diaphragm muscle

International Journal of Chronic Obstructive Pulmonary Disease, 2016
The respiratory diaphragm is the most important muscle for breathing. It contributes to various processes such as expectoration, vomiting, swallowing, urination, and defecation. It facilitates the venous and lymphatic return and helps viscera located above and below the diaphragm to work properly.
Bordoni, Bruno, Marelli,Fabiola, Morabito,Bruno, Sacconi,Beatrice   +3 more
openaire   +5 more sources

Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocin-diabetic and control rats.

Journal of Lipid Research, 1979
Several aspects of lipid metabolism in the soleus and diaphragm muscles of streptozotocin-diabetic and control rats were investigated. The triglyceride content of both muscles was elevated in the diabetic state and the presence of increased intracellular
S B Stearns, H M Tepperman, J Tepperman
doaj   +1 more source

Surface mechanomyography and electromyography provide non-invasive indices of inspiratory muscle force and activation in healthy subjects [PDF]

, 2018
The current gold standard assessment of human inspiratory muscle function involves using invasive measures of transdiaphragmatic pressure (Pdi) or crural diaphragm electromyography (oesEMGdi).
Jané Campos, Raimon, Jolley, J, Lozano, Manuel, Moxham, John, Rafferty, Gerrard F., Sarlabous Uranga, Leonardo, Torres Cebrián, Abel   +6 more
core   +2 more sources

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension [PDF]

American Journal of Respiratory and Critical Care Medicine, 2011
Recently it was suggested that patients with pulmonary hypertension (PH) suffer from inspiratory muscle dysfunction. However, the nature of inspiratory muscle weakness in PH remains unclear.To assess whether alterations in contractile performance and in morphology of the diaphragm underlie inspiratory muscle weakness in PH.PH was induced in Wistar rats
Man, F.S. de, Hees, H.W.H. van, Handoko, M.L., Niessen, H.W.M., Schalij, I., Humbert, M., Dorfmuller, P., Mercier, O., Bogaard, H.J., Postmus, P.E., Westerhof, N., Stienen, G.J., Laarse, W.J. van der, Vonk-Noordegraaf, A., Ottenheijm, C.A.C.   +14 more
openaire   +3 more sources

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources