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Genetic profile of isolated congenital diaphragmatic hernia revealed by targeted next‐generation sequencing

Prenatal Diagnosis, 2018
Congenital diaphragmatic hernia (CDH) is characterized by a defective closure of the diaphragm occurring as an isolated defect in 60% of cases. Lung size, liver herniation, and pulmonary circulation are major prognostic indices.
M. Kammoun   +9 more
semanticscholar   +1 more source

Diaphragmatic Hernia

Veterinary Clinics of North America: Small Animal Practice, 1987
This article describes the anatomy, etiology, and pathophysiology associated with congenital and traumatic diaphragmatic hernias. Suggestions on preoperative and post-operative maintenance are presented as are various techniques for surgical correction.
openaire   +2 more sources

Trends, correlates, and survival of infants with congenital diaphragmatic hernia and its subtypes.

Birth Defects Research, 2018
OBJECTIVE To identify the live-birth prevalence, trends, correlates, and neonatal and 1-year survival rates of congenital diaphragmatic hernia. METHODS Using a population-based, retrospective cohort study design, we examined 1,025 cases of congenital ...
R. Ramakrishnan   +6 more
semanticscholar   +1 more source

A systematic review with meta-analysis of the prevalence of gastroesophageal reflux in congenital diaphragmatic hernia pediatric survivors.

Diseases of the esophagus, 2018
Congenital diaphragmatic hernia survivors are a well-known group at risk for developing gastroesophageal reflux disease that may be particularly long-term severe.
J. V. Arcos-Machancoses   +3 more
semanticscholar   +1 more source

Abnormal lung development in congenital diaphragmatic hernia.

Seminars in Pediatric Surgery, 2017
The outcomes of patients diagnosed with congenital diaphragmatic hernia (CDH) have recently improved. However, mortality and morbidity remain high, and this is primarily caused by the abnormal lung development resulting in pulmonary hypoplasia and ...
Dustin Ameis   +2 more
semanticscholar   +1 more source

Epidemiology and Prognosis of Congenital Diaphragmatic Hernia: A Population-Based Cohort Study in Utah.

Birth Defects Research, 2017
BACKGROUND Congenital diaphragmatic hernia (CDH) is a relatively frequent and severe malformation. Population-based data on clinical presentation and associated mortality are scarce.
Hari Shanmugam   +4 more
semanticscholar   +1 more source

Congenital diaphragmatic hernia-associated pulmonary hypertension.

Seminars in Pediatric Surgery, 2017
Congenital diaphragmatic hernia (CDH) is a complex entity wherein a diaphragmatic defect allows intrathoracic herniation of intra-abdominal contents and both pulmonary parenchymal and vascular development are stifled.
M. Harting
semanticscholar   +1 more source

Cardiac dysfunction in congenital diaphragmatic hernia: Pathophysiology, clinical assessment, and management.

Seminars in Pediatric Surgery, 2017
Cardiac dysfunction is an important consequence of pulmonary hypertension in congenital diaphragmatic hernia and a determinant of disease severity. Increased afterload leads to right ventricular dilatation and diastolic dysfunction.
N. Patel, F. Kipfmueller
semanticscholar   +1 more source

Feasibility and Outcomes of Fetoscopic Tracheal Occlusion for Severe Left Diaphragmatic Hernia.

Obstetrics and Gynecology, 2017
OBJECTIVE To evaluate feasibility and initial outcomes of fetoscopic tracheal occlusion for severe diaphragmatic hernia compared with a historical cohort who had not received fetal tracheal occlusion.
M. Belfort   +13 more
semanticscholar   +1 more source

Congenital diaphragmatic hernia

Clinical Genetics, 1980
Background—congenital diaphragmatic hernia (CDH) has a reported incidence of 1 in 2500 to 1 in 4000 live births with an estimated 30 % spontaneous abortion rate.
openaire   +4 more sources

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