Results 41 to 50 of about 302,207 (310)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Diarrhoea, acute respiratory infection, and fever among children in the Democratic Republic of Congo [PDF]

, 2009
Several years of war have created a humanitarian crisis in the Democratic Republic of Congo (DRC) with extensive disruption of civil society, the economy and provision of basic services including health care.
Ahiadeke, Boerma, Dunyo, Einterz, Ezzati, Ezzati, Fahrmeir, Francesco P. Cappuccio, Gakidou, Guerrant, Jacques B. Emina, Kandala, Kandala, Kandala, Kandala, Kazembe, Lopez, Martin-Prével, Martorell, Ngianga-Bakwin Kandala, Parashar, Paul Denis K. Nzita, Pongou, Roberts, Smith, Snyder, UNDP, Vaahtera, Waters, Woldemicael, Yoannes   +30 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Infant feeding practices and diarrhoea in sub-Saharan African countries with high diarrhoea mortality.

PLoS ONE, 2017
BackgroundThe impacts of optimal infant feeding practices on diarrhoea have been documented in some developing countries, but not in countries with high diarrhoea mortality as reported by the World Health Organisation/United Nations Children's Fund.
Felix A Ogbo, Kingsley Agho, Pascal Ogeleka, Sue Woolfenden, Andrew Page, John Eastwood, Global Child Health Research Interest Group   +6 more
doaj   +1 more source

Antibiotic resistant Shigella is a major cause of diarrhoea in the Highlands of Papua New Guinea

Journal of Infection in Developing Countries, 2014
Introduction: Diarrhoea remains a major cause of illness in Papua New Guinea (PNG); however, little is known about its aetiology. As a result of the cholera outbreak that spread throughout PNG in 2009-2011, we conducted diarrhoeal surveillance in Eastern
Andrew R Greenhill, Carlton Guwada, Valentine Siba, Audrey Michael, Mition Yoannes, Yolandah Wawarie, Rebecca Ford, Peter M Siba, Paul F Horwood   +8 more
doaj   +1 more source

Determinants Of the Prevalence of Diarrhoea in Adolescents Attending School: A Case Study of an Indian Village School [PDF]

, 2012
In developing countries, including India, diarrhoea is a leading killer throughout the age pyramid. However, most of the medical literature on the determinants of diarrhoea focuses only on young children or the elderly, with health policy mainly ...
Arijita Dutta, Huub Meijers, Shyama V. Ramani, Timothée Frühauf   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Performance and diarrhoea in piglets following weaning at seven weeks of age: Challenge with E. coli O 149 and effect of dietary factors [PDF]

, 2009
Four dietary factors (ad libitum versus feed restriction, control versus protein restriction at ad libitum feeding, control versus inclusion of lupine as a protein source at ad libitum feeding, and control versus extra vitamin E at ad libitum feeding ...
Højsgaard, Søren, Jensen, Søren K., Lauridsen, Charlotte, Sørensen, Martin T., Vestergaard, Ellen-Margrethe   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

An Epidemiological Survey Of Diarrhoea Among Children In The Karnataka Region of Kaveri Basin

Indian Journal of Community Medicine, 1995
Research Question: Whether the source of drinking water influences the occurrence of diarrhoea in under fives? Objectives: i) To know the incidence of morbidity and mortality due to diarrhoea.
Sudarshan M.K, Parasuramalu B.G
doaj