Results 211 to 220 of about 54,248 (321)

A ‘fluttering’ diastolic murmur [PDF]

open access: yesEuropean Heart Journal - Cardiovascular Imaging, 2018
Sami Firoozi   +3 more
openaire   +3 more sources

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

open access: yesChemMedChem, EarlyView.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés   +7 more
wiley   +1 more source

Noninvasive assessment of myocardial perfusion using ultrafast ultrasound: clinical study for congenital heart disease. [PDF]

open access: yesEur Heart J Imaging Methods Pract
Nguyen MB   +7 more
europepmc   +1 more source

Functional characteristics of intramyocardial capacitance vessels during diastole in the dog. [PDF]

open access: bronze, 1986
Fumihiko Kajiya   +9 more
openalex   +1 more source

A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison   +7 more
wiley   +1 more source

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