Results 131 to 140 of about 5,364,392 (254)

Blood pressure-lowering for prevention of major cardiovascular diseases in isolated diastolic hypertension: an individual participant-level data meta-analysis of randomised controlled trials

Background and Aims: Blood Pressure (BP) lowering reduces cardiovascular disease (CVD) risk, however, the benefits of treating patients with normal systolic BP but elevated diastolic BP remain uncertain. Methods: Data from 51 randomised controlled trials
Canoy, Dexter, Maimaitiaili, Rusitanmujiang, Rahimi, Kazem, Teo, Koon K, Davis, Barry R, Nazarzadeh Larzjan, Milad, McEvoy, John William, Bidel, Zeinab, Pepine, Carl J, Chalmers, John   +9 more
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Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Hoti, M, Caulfield, M, Lee, K, Samani, NJ, Elliott, P, Collins, R, Org, E, Farrall, M, Newhouse, S, Juhanson, P, Connell, JM, Ji, C, Burke, B, Viigimaa, M, Shaw-Hawkins, S, Veldre, G, Dobson, R, Kumari, M, Lathrop, GM, Iacone, R, Brunner, E, Dominiczak, AF, Strazzullo, P, Eyheramendy, S, Onipinla, A, Clarke, R, Chambers, J, Howard, P, Cappucio, FP, Marmot, M, Munroe, PB, Wallace, C, Kooner, J, Brown, M, Laan, M   +34 more
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Comparison of Immediate Versus Staged Complete Revascularization in Patients With Index PCI Coronary Complications: A Study on Clinical Outcomes and Predictors of Complications

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background In patients with acute coronary syndrome (ACS) and multivessel disease (MVD), complete revascularization (CR) improves clinical outcomes compared with culprit‐only percutaneous coronary intervention (PCI). However, the optimal timing of CR, immediate (ICR) versus staged (SCR), remains debated.
Alessandro Gabrielli, Jacob J. Elscot, William Camilleri, Hala Kakar, Eric Boersma, Nicolas M. Van Mieghem, Roberto Diletti, Wijnand K. Den Dekker   +7 more
wiley   +1 more source

Coronary Flow in Hypertrophic Obstructive Cardiomyopathy—Immediate Effects of Alcohol Septal Ablation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Hypertrophic cardiomyopathy is associated with alterations in coronary microvascular function which have variable pathophysiologic mechanisms, and variable reversibility acutely and chronically following alcohol septal ablation (ASA).
Vojko V. Misevic, Ana N. Golocevac, Kosta S. Krupnikovic, Stefan B. Timcic, Natalija B. Arnautovic, Dragana D. Radoicic, Milan R. Dobric, Aleksandar D. Mandic, Stefan S. Zivkovic, Aleksa D. Obradovic, Vladimir D. Mihajlovic, Natalija R. Odanovic, Ivan S. Ilic   +12 more
wiley   +1 more source

Clinical Outcomes of the Allegra Transcatheter System in Bioprosthetic Aortic Valve Failure: A Multicentre Valve‐in‐Valve Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Introduction The prevalence of bioprosthetic aortic valve failure is increasing due to the broader use of bioprosthetic valves, both surgical and transcatheter, and an ageing population. Registry data indicate a higher risk of coronary obstruction and elevated gradients following valve‐in‐valve transcatheter aortic valve implantation (TAVI ...
Hilal Khan, Mohamed Ali, Abdalazeem Ibrahem, Karim Ratib, Nur Ilia Mohd Zaki, Freidoon Keshavarzi, Alok Shah, Hesham Abdelaziz, Ayush Khurana, Alexander Chase, Diana A. Gorog, Rajiv Das, Azfar Zaman, Mohammad AlKhalil, Mohamed Farag   +14 more
wiley   +1 more source

Clinical Impact of Adherence to Fractional Flow Reserve Guidance in Acute Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Fractional flow reserve (FFR) is established to guide revascularization in stable coronary disease and non‐culprit lesions in acute coronary syndromes (ACS). However, real‐world adherence to FFR guidance across the spectrum of ACS presentations, including ambiguous culprit scenarios, remains incompletely characterized.
Eun Ho Choo, Ik Jun Choi, Sungmin Lim, Donggyu Moon, Dae‐Won Kim, Kiyuk Chang   +5 more
wiley   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Orthostatic diastolic blood pressure variability links autonomic regulation to recurrence of benign paroxysmal positional vertigo

Retrospective observational clinical study data. We investigated diastolic blood pressure variability during the early phase of orthostatic challenge as an index of dynamic autonomic regulation.
RHIM, GU IL
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UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Twenty-four-hour ambulatory blood-pressure variability is associated with total magnetic resonance-imaging burden in cerebral small-vessel disease

, 2018
Shuna Yang,* Junliang Yuan,* Wei Qin, Lei Yang, Huimin Fan, Yue Li, Wenli Hu Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background: Lacunae, brain ...
Li Y, Fan H, Yang L, Hu W, Qin W, Yang S, Yuan J   +6 more
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