Results 201 to 210 of about 427,110 (327)

Invited letter concerning: Dynamic cardiomyoplasty acutely impairs left ventricular diastolic function

, 1993
Larry W. Stephenson
openalex   +1 more source

Pharmacokinetics and Bioequivalence of a Novel Extended‐Release Formulation of Methylphenidate Hydrochloride for Attention‐Deficit/Hyperactivity Disorder

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Extended‐release (ER) formulations of the stimulant methylphenidate are commonly used to treat attention‐deficit/hyperactivity disorder in both children and adults. Previous studies have shown that the clinical effectiveness of long‐acting methylphenidate formulations is closely tied to the drug's pharmacokinetic (PK) profile, highlighting the
Ann C. Childress, Ahmad AL‐Sabbagh, Jeffrey H. Newcorn   +2 more
wiley   +1 more source

Relationship between carotid-femoral pulse wave velocity and decreased left ventricular diastolic function in patient with coronary heart disease: a cross-sectional study. [PDF]

Front Cardiovasc Med
Gu H, Liang G, Zhang W, Gu X, Zhang Q, Ma J.   +5 more
europepmc   +1 more source

Correlation between left ventricular diastolic function before and after valve replacement surgery and myocardial ultrastructural changes in patients with left ventricular volume-overloaded valvular heart diseases

, 1993
Tomiro OKADA
openalex   +2 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Assessment of Diastolic Function during the transitional period and infancy using Serial Echocardiography in a tertiary neonatal unit (DiFuSE): a longitudinal prospective observational study protocol. [PDF]

BMJ Open
Stapleton I, Bussmann N, Finn D, Livingstone V, Dempsey E.   +4 more
europepmc   +1 more source

Maternal cardiac systolic and diastolic function: relationship with uteroplacental resistances. A Doppler and echocardiographic longitudinal study [PDF]

, 2000
Herbert Valensise, G. P. Novelli, B. Vasapollo, M. Borzi, Domenico Arduini, A. Galante, Carlo Romaninï   +6 more
openalex   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

Clinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre, Gerard Sanacora, David P. Walling, Elan A. Cohen, Shishuka Malhotra, Holger Rosenbrock, Manuela Schmitz, Andreas Scholz, Sigurd D. Süssmuth, Franco De Crescenzo   +9 more
wiley   +1 more source

Simple and Practical Way of Assessing Diastolic Function: Diastolic Heart Failure Revisited. [PDF]

Korean Circ J
Sohn DW.
europepmc   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source