Results 101 to 110 of about 86,598 (299)

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

open access: yesEpilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong   +5 more
wiley   +1 more source

Epilepsy in dentatorubral–pallidoluysian atrophy: A systematic review and meta‐analysis

open access: yesEpilepsia, EarlyView.
Summary of key clinical and electrophysiological characteristics of DRPLA‐related epilepsy from a systematic review and meta‐analysis of 1,191 patients. DRPLA patients with epilepsy showed earlier disease onset, longer CAG repeat expansion, and a tendency toward paternal inheritance. EEG findings frequently included photoparoxysmal responses.
Toru Horinouchi   +10 more
wiley   +1 more source

Equivalencia terapéutica de tabletas de diazepam dispensadas en la ciudad de Ica, Perú

open access: yesRevista Médica Herediana, 2012
Objetivos: Determinar la equivalencia terapéutica in vitro de tres formulaciones de diazepam 10 mg tabletas, para establecer su intercambiabilidad con el medicamento de referencia original.
Oscar Herrera-Calderon   +1 more
doaj  

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

open access: yesEpilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante   +4 more
wiley   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

open access: yesEpilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi   +7 more
wiley   +1 more source

Investigation effcct of propofol when added to xylazine-diazepam-ketamine anaesthetic combination in horses [PDF]

open access: yesEurasian Journal of Veterinary Sciences
The aim ot this study was to determine the effects of propofol when added to xylazine-diazepam-kelam ine anaesthetic combination in horse anaesthesia Oy evaluation ol some cardiopulmonary, hematological, biochemical and clinical anaesthetic parameters ...
Cengiz Ceylan   +3 more
doaj  

Borna disease virus infection: Retrospective case series of five horses and two donkeys in Switzerland

open access: yesEquine Veterinary Education, EarlyView.
Summary Borna disease is an acute to subacute, rarely chronic non‐purulent meningoencephaylomyelitis affecting mainly horses and sheep. This case series describes the clinical signs, diagnosis, treatment, outcome and post‐mortem findings of five horses and two donkeys with this condition. The equids affected were geldings or mares of various breeds and
I. L. Piotrowski, M. Hilbe, H. K. Junge
wiley   +1 more source

Surgical management of carpus valgus deformity caused by persistent ulna in three large breed foals

open access: yesEquine Veterinary Education, EarlyView.
Summary This case series describes the occurrence of persistent ulnar remnants in three large breed foals presented with bilateral carpus valgus deformity. Distal ulnar ossification was diagnosed based on lateromedial radiographic projections. Treatment included distal ulna ostectomy in conjunction with transphyseal screw placement or periosteal ...
A. C. Müller   +4 more
wiley   +1 more source

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