Results 161 to 170 of about 144,206 (380)

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan   +10 more
wiley   +1 more source

Management of epilepsy [PDF]

open access: yes, 1989
Figures for the incidence of epilepsy in Malta are not available. The overall figure for epilepsy given by the Royal College of General Practitioners (Reid 1960) is 4.82 per 1,000 population.
Galea Debono, Anthony
core  

Dual Growth Factor Release From Collagen Based Multilayer Films on Ti‐Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In‐Vivo Study

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives The aim of the present study was to assess the effect of dual growth factor release from collagen‐based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.
Philipp Kauffmann   +7 more
wiley   +1 more source

The reliability and validity of functional brain connectivity compared to a self-reported measure of pain [PDF]

open access: yes, 2016
Pain is a multidimensional perception that is complex in nature. It is a unitary construct that includes overlapping domains such as intensity, affect, quality, and frequency. These domains do not reflect the amount of tissue damage.
Alsouhibani, Ali
core   +1 more source

Time Course of Ventilatory Response to Carbon Dioxide after Intravenous Diazepam [PDF]

open access: bronze, 1982
Jeffrey B. Gross   +2 more
openalex   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

open access: yesEpilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Fluoxetine and diazepam acutely modulate stress induced-behavior

open access: yesBehavioural Brain Research, 2016
A. C. Giacomini   +9 more
semanticscholar   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

open access: yesEpilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson   +9 more
wiley   +1 more source

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