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Anesthesiology, 1969 Some of the next articles are maybe not open access.
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JAMA: The Journal of the American Medical Association, 1971
To the Editor.— In response to the article by Barrett and Hey ( 214: 1323,1970), I find it very difficult to implicate diazepam as the toxic agent producing the ventricular arrhythmias described. In the first case, the patient had a history of "chronic bronchitis" and may well have had hypoxia or respiratory acidosis, or both, which was aggravated by
A P, Naney, W G, Chaffee
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To the Editor.— In response to the article by Barrett and Hey ( 214: 1323,1970), I find it very difficult to implicate diazepam as the toxic agent producing the ventricular arrhythmias described. In the first case, the patient had a history of "chronic bronchitis" and may well have had hypoxia or respiratory acidosis, or both, which was aggravated by
A P, Naney, W G, Chaffee
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American Journal of Psychiatry, 1984
Intravenous diazepam rapidly relieved catatonic immobility in two schizophrenic patients, and oral diazepam maintained this therapeutic effect. Diazepam may be an immediately available and effective treatment for some patients with life-threatening catatonic disorders.
Joseph P. McEvoy, Lohr Jb
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Intravenous diazepam rapidly relieved catatonic immobility in two schizophrenic patients, and oral diazepam maintained this therapeutic effect. Diazepam may be an immediately available and effective treatment for some patients with life-threatening catatonic disorders.
Joseph P. McEvoy, Lohr Jb
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International Journal of the Addictions, 1976
Literature is reviewed which raises the question of diazepam's addicting potential. To explore this issue, 50 subjects referred from medical, surgical, and psychiatric clinics were evaluated by interview regarding their use of diazepam. Replies to a standardized interview were combined with physicians' ratings of addiction under two conditions: without
James Klotter, Barry M. Maletzky
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Literature is reviewed which raises the question of diazepam's addicting potential. To explore this issue, 50 subjects referred from medical, surgical, and psychiatric clinics were evaluated by interview regarding their use of diazepam. Replies to a standardized interview were combined with physicians' ratings of addiction under two conditions: without
James Klotter, Barry M. Maletzky
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Acta Medica Scandinavica, 1975
Abstract Diazepam has been used to an increasing extent in cardioversion, since avoiding general anaesthesia simplifies the procedure. The present study concerns the effect of diazepam on BP and blood gases in 13 cases of cardioversion. A moderate fall of both systolic and diastolic BP occurred. The arterial pO2 and pCO2 did not change significantly.
O. Nyquist +3 more
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Abstract Diazepam has been used to an increasing extent in cardioversion, since avoiding general anaesthesia simplifies the procedure. The present study concerns the effect of diazepam on BP and blood gases in 13 cases of cardioversion. A moderate fall of both systolic and diastolic BP occurred. The arterial pO2 and pCO2 did not change significantly.
O. Nyquist +3 more
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New England Journal of Medicine, 1965
THE conversion of cardiac arrhythmias by directcurrent countershock has become widely accepted but has usually required the use of general anesthesia, with its attendant hazards and practical problems. The last 15 patients undergoing cardioversion in our laboratory have been prepared for electric shock with a single intravenous injection of diazepam ...
D. O. Nutter, R. A. Massumi
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THE conversion of cardiac arrhythmias by directcurrent countershock has become widely accepted but has usually required the use of general anesthesia, with its attendant hazards and practical problems. The last 15 patients undergoing cardioversion in our laboratory have been prepared for electric shock with a single intravenous injection of diazepam ...
D. O. Nutter, R. A. Massumi
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CARDIOPULMONARY EFFECTS OF DIAZEPAM
Survey of Anesthesiology, 1973Eighteen patients with appreciable obstructive lung disease and 18 patients without measurable mechanical lung impairment were given intravenous diazepam to permit endoscopy. Doses of diazepam required for comparable level of anesthesia were used. There was an increase in the heart rate, and there were decreases in the blood pressure, stroke volume ...
K. Prasad +4 more
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Allergy, 2002
A 28-year-old nurse experienced collapse and generalized urticaria while she was undergoing a gastroscopy for suspected Helicobacter pylori infection. Before the start of the procedure, lidocaine (lignocaine) oral spray and 10 mg intravenous diazepam was administered; in addition, 1 mg flumazenil was given intravenously at the end of gastroscopy.
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A 28-year-old nurse experienced collapse and generalized urticaria while she was undergoing a gastroscopy for suspected Helicobacter pylori infection. Before the start of the procedure, lidocaine (lignocaine) oral spray and 10 mg intravenous diazepam was administered; in addition, 1 mg flumazenil was given intravenously at the end of gastroscopy.
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Metabolism of diazepam in rabbits
Archives of Biochemistry and Biophysics, 1964Abstract Urines of rabbits treated with large doses of diazepam were analyzed. After hydrolysis three compounds were isolated and identified: 2-methylamino-5-chlorobenzophenone (III), 2-amino-5-chlorobenzophenone (IV), and 2-methylamino-5-chloro-4′-hydroxybenzophenone (V).
G. Jommi, P. Manitto, M.A. Silanos
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Potencies of diazepam metabolites in rats trained to discriminate diazepam
Life Sciences, 1986The dose-response relationships of diazepam and several of its metabolites were determined in rats trained to discriminate diazepam (3 mg/kg) from saline in a two-lever operant choice task. Generalization of the diazepam stimulus was found to occur with temazepam and oxazepam, which were nearly equipotent with diazepam, and also with desmethyldiazepam,
David A. Brase +3 more
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