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A Phase 3 open‐label safety study (NCT02721069) evaluated long‐term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.
James Wheless, Ian Miller, Robert Hogan
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The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product ...
Robert Hogan +2 more
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Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood ...
Michael A Van Der Kooij +2 more
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Classics in Chemical Neuroscience: Diazepam (Valium)
James C Barrow
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Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles
Rakesh Kumar Sharma +2 more
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