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Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy

open access: yesEpilepsia, 2021
A Phase 3 open‐label safety study (NCT02721069) evaluated long‐term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.
James Wheless, Ian Miller, Robert Hogan
exaly   +2 more sources
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Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

open access: yesEpilepsia, 2020
The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product ...
Robert Hogan   +2 more
exaly   +2 more sources

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors

open access: yesMolecular Psychiatry, 2017
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood ...
Michael A Van Der Kooij   +2 more
exaly   +2 more sources

Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles

open access: yesAAPS PharmSciTech, 2015
Rakesh Kumar Sharma   +2 more
exaly   +2 more sources

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