The potential of dibenzazepine carboxamides in cancer therapy [PDF]
Frontiers in PharmacologyCancer is a leading cause of mortality worldwide, with most conventional treatments lacking efficacy and having significant challenges like drug resistance. Finding new molecules is quite challenging in terms of cost, time and setbacks.
Nastaran Afsordeh +3 more
doaj +3 more sources
Initial monotherapy with eslicarbazepine acetate for the management of adult patients with focal epilepsy in clinical practice: a meta-analysis of observational studies [PDF]
, 2023 To assess the effectiveness, overall tolerability of eslicarbazepine acetate (ESL) as an initial or early monotherapy treatment of adult patients with focal epilepsy under real-world practice conditions. We focused on real-world longitudinal studies that
Fernández-Anaya, Silvia +5 more
core +5 more sources
Predicting the impacts of chemical pollutants on animal groups [PDF]
, 2022 Wildlife are exposed to an increasing number and diversity of chemical pollutants.Chemical pollutants can elicit a range of sublethal effects on individual organisms, but research on how these contaminants affect social interactions and animal groups is ...
Bertram, Michael +6 more
core +6 more sources
Immobilized Rose Bengal as Photocatalyst for Metal‐Free Thiocyanation of Azaheterocycles under Continuous Flow Conditions [PDF]
, 2023 The immobilization of Rose Bengal onto Merrifield resin and its application in the light-driven metal-free thiocyanation of azaheterocycles in continuo were investigated.
Alessandra Puglisi +4 more
core +1 more source
The evidence for switching dibenzazepines in people with epilepsy [PDF]
, 2020 This is the author accepted manuscript. The final version is available on open access from Wiley via the DOI in this recordThe dibenzazepines particularly carbamazepine are associated with known adverse effects (AEs) and drug to drug interactions ...
Lawthom, C +6 more
core +3 more sources
EPR studies on the addition of ligated boryl radicals to carbonyl compounds [PDF]
, 2020 J.C.W. thanks EaStCHEM for financial support and D.P.C. thanks the US National Science Foundation. Computational support was provided through the EaStCHEM Research Computing Facility.The boron-centered radicals derived from alkenyl N-heterocyclic carbene
Curran, Dennis P. +2 more
core +2 more sources
Pharmaceuticals, 2010 The recent review of Matthew D. Krasowski on ‘Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications’ is a useful foundation of comparative interpretations on our current knowledge about therapeutic drug monitoring.
Patricio Soares-da-Silva +1 more
doaj +1 more source
Structure-based discovery of novel US28 small molecule ligands with different modes of action [PDF]
, 2017 The human cytomegalovirus-encoded G protein-coupled receptor US28 is a constitutively active receptor, which can recognize various chemokines. Despite the recent determination of its 2.9 Å crystal structure, potent and US28-specific tool compounds are ...
Abrahamian +41 more
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Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. [PDF]
, 2014 Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of ...
Andres Obregón‐Henao +22 more
core +3 more sources
Photocatalytic Difluoromethylation Reactions of Aromatic Compounds and Aliphatic Multiple C-C Bonds [PDF]
, 2019 Among the realm of visible light photocatalytic transformations, late-stagedifluoromethylation reactions (introduction of difluoromethyl groups in the last stages of syntheticprotocols) have played relevant roles as the CF2X group substitutions exert ...
Barata Vallejo, Sebastian +1 more
core +1 more source