Results 11 to 20 of about 529 (153)

Iodine(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines. [PDF]

Chemistry, 2023
Abstract The development of an efficient process that produces bioactive medium‐sized N ‐heterocyclic scaffolds from 2‐substituted anilines using either iodosobenzene or (bis(trifluoroacetoxy)iodo)‐benzene is reported.
White CM, Zorigt N, Deng T, Driver TG.
europepmc   +4 more sources

Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms. [PDF]

Acta Crystallogr F Struct Biol Commun, 2023
The structure of the imine reductase from A. dermatitidis is presented in three crystal forms, each of which provides information on conformational dynamics and cofactor and substrate binding within the enzyme.The NADPH‐dependent imine reductase from Ajellomyces dermatitidis (AdRedAm) catalyzes the reductive amination of certain ketones with amine ...
Sharma M, Cuetos A, Willliams A, González-Martínez D, Grogan G.   +4 more
europepmc   +2 more sources

Eslicarbazepine-induced hyponatremia: A retrospective single-center real clinical practice study. [PDF]

Epilepsia Open
Abstract Hyponatremia is a typical side effect of antiseizure drugs from the dibenzazepine family. The study investigated the prevalence of hyponatremia in patients with epilepsy who were treated with eslicarbazepine. We aimed to determine the prevalence of hyponatremia, reveal the factors leading to the discontinuation of treatment, and identify ...
Strýček O, Všianský V, Doležalová I, Kočvarová J, Pail M, Brázdil M.   +5 more
europepmc   +2 more sources

Long-term effects of adjunctive eslicarbazepine acetate in adult Asian patients with refractory focal seizures: Post hoc analysis of a phase III trial. [PDF]

Clin Transl Sci
Abstract A post hoc analysis of data from Asian patients included in the study BIA‐2093‐304 was conducted to evaluate the long‐term safety/tolerability and efficacy of adjunctive eslicarbazepine acetate (ESL) in adult Asian patients with refractory focal seizures.
Lee SK, Lee SA, Hong SB, Cho YW, Castilla-Fernández G, Fonseca MM, Moreira J, Gama H, Holenz J.   +8 more
europepmc   +2 more sources

A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines. [PDF]

Chem Rec
This review summarizes recent advances in dibenzo[b,f]oxepine synthesis, highlighting medicinal and materials applications. It discusses classical and modern methods, including cross‐coupling, intramolecular cyclizations, and diversification strategies, emphasizing efficiency, selectivity, and sustainability. Emerging trends such as greener approaches,
da Costa GP, Schneider BR, Barcellos AM, Soares LK, Brinkerhoff RC, Ludwig FP, Flores AFC.   +6 more
europepmc   +2 more sources

Sulfur‐Centered Radicals in Visible Light Isocyanide Photochemistry

European Journal of Organic Chemistry, Volume 26, Issue 45, December 1, 2023., 2023
Sulfur‐centered radicals have a key role in a plethora of synthetic transformations, whose scope is ever‐expanding thanks to visible light photocatalysis. The current review focuses on those transformations involving isocyanides and S‐centered radicals and aims to highlight the chemical space accessible and the mechanistic rational underpinning current
Camilla Russo, Francesca Brunelli, Gian Cesare Tron, Mariateresa Giustiniano   +3 more
wiley   +1 more source

Iron‐responsive element of Divalent metal transporter 1 (Dmt1) controls Notch‐mediated cell fates

The FEBS Journal, Volume 290, Issue 24, Page 5811-5834, December 2023., 2023
Divalent metal transporter 1 (Dmt1)‐deficient cells exhibit perturbations in vesicle function and excessive ROS leading to a loss of Notch activity. The effect varies depending on the isoforms of Dmt1. Inhibition of Dmt1 lacking an iron‐responsive element (Dmt1‐ire) blocks Notch activity, leading to a Notch‐dependent accelerated differentiation in ...
Judith Hounjet, Arjan J. Groot, Jolanda P. Piepers, Onno Kranenburg, Danny A. Zwijnenburg, Francesca A. Rapino, Jan B. Koster, Kim R. Kampen, Marc A. Vooijs   +8 more
wiley   +1 more source

Recent Advances in Visible Light‐Mediated Radical Fluoro‐alkylation, ‐alkoxylation, ‐alkylthiolation, ‐alkylselenolation, and ‐alkylamination

The Chemical Record, Volume 23, Issue 9, September 2023., 2023
In recent years, the rise of both organofluorine chemistry and photochemistry have intersected to bring about a myriad of visible light‐mediated protocols. The development of new reagents and advances in photo‐mediated processes have synergistically provided mild, effective, and reliable fluorine‐related transformations.
Daniel Lin, Matthew Coe, Vinayak Krishnamurti, Xanath Ispizua‐Rodriguez, G. K. Surya Prakash   +4 more
wiley   +1 more source

An Iminostilbene Functionalized Benzimidazoline for Enhanced n‐Type Solution Doping of Semiconducting Polymers for Organic Thermoelectrics

Advanced Materials Interfaces, Volume 10, Issue 19, July 6, 2023., 2023
The development of organic thermoelectric generators requires better performing molecular n‐type dopants. The synthesis of a novel benzimidazoline derivative functionalized with a rigid and planarized iminostilbene substituent is reported here. Such chemical modification emerges as a feasible strategy to enhance the electrical conductivity and the ...
Pietro Rossi, Francesca Pallini, Giulia Coco, Sara Mattiello, Wen Liang Tan, Lorenzo Mezzomo, Marco Cassinelli, Guglielmo Lanzani, Christopher R. McNeill, Luca Beverina, Mario Caironi   +10 more
wiley   +1 more source

Adsorption of Carbamazepine in All‐Silica Zeolites Studied with Density Functional Theory Calculations**

ChemPhysChem, Volume 24, Issue 9, May 2, 2023., 2023
The interaction of carbamazepine with eleven all‐silica zeolites is studied using dispersion‐corrected density functional theory calculations. The calculations not only allow the prediction of highly promising adsorbents for carbamazepine removal, but also provide insights into the role of host‐guest and guest‐guest interactions.
Michael Fischer
wiley   +1 more source