The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs [PDF]
, 2016 The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an
Ita, Kevin B. +3 more
core +3 more sources
Unsymmetrically-Substituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione Scaffold—A Useful Tool for Bioactive Molecules Design [PDF]
, 2020 Unsymmetrically N-substituted and N,N’-disubstituted 5,12-dihydrodibenzo [b,f][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the dibenzodiazocine scaffold were introduced at the stages of proper selection of
Bieszczad, Bartosz +6 more
core +1 more source
Dibenzazepine Agents in Epilepsy: How Does Eslicarbazepine Acetate Differ? [PDF]
Neurology and Therapy, 2018 Carbamazepine (CBZ), oxcarbazepine (OXC), and eslicarbazepine acetate (ESL) belong to the dibenzazepine family of antiepileptic drugs and are all thought to primarily act as sodium channel blockers (SCBs). However, ESL is structurally distinct from CBZ and OXC, resulting in differences in metabolism, pharmacokinetics, and pharmacodynamics.
Charlotte Lawthom +4 more
openaire +3 more sources
Structures of Ebola virus glycoprotein complexes with tricyclic antidepressant and antipsychotic drugs [PDF]
, 2018 A large number of Food and Drug Administration (FDA)-approved drugs have been found to inhibit the cell entry of Ebola virus (EBOV). However, since these drugs have various primary pharmacological targets, their mechanisms of action against EBOV remain ...
Fry, Elizabeth E +5 more
core +4 more sources
Dibenzazepine Bridged Network Polymeric Phthalocyanines as Degradable Heterogeneous Photocatalysts
Angewandte Chemie International Edition, EarlyView.Dibenzazepine photodynamic bridge has been introduced to zinc and cobalt networks phthalocyanines (NP‐Pcs) to obtain degradable heterogeneous photocatalysts. For the first time, light irradiation plays a key role in “design, use and degradation” of NP‐Pcs.
Erem Ahmetali +4 more
wiley +1 more source
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, Volume 12, Issue 48, December 29, 2025.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
Homogeneous rhodium(I)-catalysis in de novo heterocycle syntheses [PDF]
, 2016 Recent research has led to the development of mild, efficient and selective catalytic systems based on Rh(I) complexes. This review summarises the applications of these catalysts to the synthesis of heterocycles from simple building blocks.
Neuhaus, James D., Willis, Michael
core +2 more sources
I(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines
, 2023 The development of an efficient process that produces bioactive medium-sized N-heterocyclic scaffolds from 2-substituted anilines using an iodine(III)-oxidant is reported. Construction of the medium-sized ring is mild, occurs at room temperature, and proceeds via cationic reactive intermediates.
Carmen Margaret White +3 more
openaire +1 more source
Investigating pharmacotherapies for alcohol use disorder using Drosophila melanogaster
Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2294-2309, October 2025.This study validates Drosophila melanogaster as a powerful model for alcohol use disorder (AUD) drug discovery. A pipeline to test drug effects on acute alcohol response, alcohol consumption, and memory for alcohol reward was developed, then validated using naltrexone and acamprosate, which effectively reduced alcohol preference and associated memory ...
Rebecca Oramas +5 more
wiley +1 more source
Electrifying green synthesis: recent advances in electrochemical annulation reactions [PDF]
, 2020 Electricity originating from renewable resources can be used for highly sustainable and economically attractive applications. With electrons as the mass-free reagent, the use of a stoichiometric amount of oxidants in annulation reactions can be avoided ...
Ahmed, Nisar +3 more
core +2 more sources