Results 41 to 50 of about 529 (153)
Visceral leishmaniasis – malaria co-infections:Epidemiological, immunological and parasitological aspects [PDF]
, 2017 Concomitant infections by multiple pathogen species represent a serious threat to human health. Affecting over a billion people worldwide, co-infections are an important cause of human morbidity and mortality, and a powerful driver of pathogen evolution.
van den Bogaart, E.
core +2 more sources
Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design [PDF]
, 2007 Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people worldwide.
Khan, M. O. Faruk
core +4 more sources
, 2021 While non-headache, non-oral craniofacial neuralgia is relatively rare in incidence and prevalence, it can result in debilitating pain. Understanding the relevant anatomy of peripheral branches of nerves, natural history, clinical presentation, and ...
Katta-Charles, Sheryl D.
core +1 more source
Intracellular Trafficking Defects in Congenital Intestinal and Hepatic Diseases
Traffic, Volume 25, Issue 8, August 2024.In this study, we investigated errors of polarized protein trafficking leading to congenital intestinal or hepatic illnesses. We provide an up‐to‐date overview of the affected genes and related trafficking machineries, disease‐relevant pathomechanisms, as well as insights into the novelties of the field.
Luca Szabó +2 more
wiley +1 more source
Three-dimensional printing in catalysis: Development of reusable metal-silica monolithic catalysts and catalytic devices for solution phase chemistry and drug discovery [PDF]
, 2020 The main objective of this Thesis was the application of 3D-printing technology to the manufacture of diverse catalytic devices, applicable to catalytic drug syntheses, mainly aimed at the Pharmaceutical Industry, contributing at the same time to the ...
Sánchez Díaz-Marta, Antonio
core
Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity [PDF]
Molecular Therapy, 2017 Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the location and temporal extent of beige adipocyte ...
Chunhui, Jiang +8 more
openaire +3 more sources
Physiological Reports, Volume 12, Issue 12, June 2024.Aging is accompanied with changes in (i) signaling pathways that regulate the aging process, that is, TOR, AMPK, insulin/IGF‐1, TGF‐beta, NF‐kB, PI3K, MAPK, PKC, Notch and Wnt; (ii) activity and responsiveness of the renin–angiotensin system (RAS); (iii) epigenetic modulation of gene expression. These changes negatively impact on mitochondrial function,
Elena M. V. de Cavanagh +2 more
wiley +1 more source
Synthesis, antimalarial activity, and target binding of dibenzazepine-tethered isoxazolines [PDF]
RSC Advances, 2015 A series of dibenzazepine tethered 3,5-disubstituted isoxazolines was synthesized and evaluated for their antimalarial activity usingP. falciparum3D7 strain. Further, the potent molecules were assessed againstP. falciparumD6, W2 and 7G8 strains.
Vinay Kumar, K. S. +8 more
openaire +2 more sources
Visible‐Light‐Driven Cyclizations
Advanced Synthesis &Catalysis, Volume 366, Issue 4, Page 635-697, February 20, 2024.Abstract In recent years, the interest to develop cyclizations promoted by visible light has been gaining a lot of attention due to its sustainability aspect. In this review, we summarize the most important advances in this period by describing the methods used to generate different ring sizes, while focusing on the mechanistic details of these ...
Emilia Oueis, Mirella Elkadi, Ramon Rios
wiley +1 more source
Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates [PDF]
, 2019 Although solubility-pH data for desipramine hydrochloride (DsHCl) have been reported previously, the aim of the present study was to critically examine the aqueous solubility-pH behavior of DsHCl in buffer-free and buffered solutions, in the presence of ...
Avdeef, Alex +5 more
core +6 more sources