Methods for Arylethylation of Amines and Heteroarenes [PDF]
, 2018 Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging.
Bracher, Franz
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Experimental Dermatology, Volume 33, Issue 1, January 2024.Abstract Notch signalling has generated considerable interest as a pathogenetic factor and a drug target in a range of human diseases. The gamma‐secretase complex is crucial in the activation of Notch receptors by cleaving the intracellular domain allowing nuclear translocation.
Siri Hansen Stabell +6 more
wiley +1 more source
Dibenzazepin assoziierte sekretorische Transformation und Bakterizidie enterozytärer Zellen
, 2022 Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2022; Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen, Diagramme (2022).
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Carbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers. Access to Pyrrolo[1,2-b]isoquinolines [PDF]
, 2019 A convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been developed, that implies a sequential Pd(0)-catalyzed carbopalladation followed by cross-coupling reaction with boronic acids.
Barbolla Cuadrado, Iratxe +2 more
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Homoheteroaromaticity: the case study of azepine and dibenzazepine.
Organic & biomolecular chemistry, 2004 Geometrical and energetic DFT calculations as well as GIAO and NICS chemical shifts have been calculated for 1H-azepine and 5H-dibenz[b,f]azepine and their cations. The last compound has been studied experimentally by 1H and 13C NMR in neutral and acidic conditions establishing that the cation corresponds to an N-protonated structure. The conclusion is
Dardonville, Christophe +3 more
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A brief review on carbamazepine: history, pharmacological properties and environmental impact [PDF]
, 2022 Schwarz, Amelie +2 more
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SYNTHESIS AND ANTICONVULSANT ACTIVITY (CHEMO SHOCK) OF N-1(SUBSTITUTED-N-4[(4-OXO-3-PHENYL-3, 4-DIHYDRO-QUINAZOLINE-2-YLMETHYL) SEMICARBAZONES [PDF]
, 2017 Objective: This work is designed at finding new structure leads with potential anticonvulsant activities of 4(3H)-quinazolinone pharmacophore scaffold.Methods: A new series of 4(3H)-quinazolinone pharmacophore was designed with substituted moieties ...
Goswami, Diptendu +2 more
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Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments [PDF]
, 2023 Research into the involvement of adrenoceptor subtypes in the cause(s) of psychiatric disorders is particularly challenging. This is partly because of difficulties in developing animal models that recapitulate the human condition but also because no ...
Heal, David J, Stanford, S Clare
core
Discovering new transmission-blocking antimalarial compounds : challenges and opportunities [PDF]
, 2016 The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it 1) target only parasite transmission stages; 2) be combined with a
Alano, Pietro +4 more
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Tardive Dyskinesia: Barriers to the Professional Recognition of an Iatrogenic Disease [PDF]
, 1986 Tardive dyskinesia (TD), once regarded by psychiatrists as a rare occurrence, is currently recognized as the most pervasive side effect (other than sedation) ofantipsychotic medication.
Phil Brown, Steven C. Funk
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