Results 41 to 50 of about 283 (127)

Antioxidant Potential and Chemotherapy-Modulating Effects of Shilajit in A549 Lung Cancer Cells [PDF]

Objective: In this study, the antioxidant and chemotherapy-modulating effects of shilajit, a natural humic substance, on the human lung adenocarcinoma cell line (A549) were investigated.Material-Method: Shilajit extracts (water and DMEM solvent) were ...
Fadime Ovalı, Fatma Şengül Bağ, Hüsamettin Vatansev   +2 more
core   +2 more sources

Polyphenols as Wnt/β‐catenin pathway modulators: A promising strategy in clinical neurodegeneration

Animal Models and Experimental Medicine, Volume 8, Issue 2, Page 266-286, February 2025.
Polyphenols as therapeutic agents in neurodegenerative diseases (NDs): polyphenols, found in plants, have potential therapeutic properties in treating NDs. The Wnt/β‐catenin (WβC) signaling pathway is involved in neurogenesis, neuronal survival, and synaptic plasticity. Dysregulation of this pathway is a hallmark of NDs.
Biswajit Kumar Utpal, Sajib Chandra Roy, Mehrukh Zehravi, Sherouk Hussein Sweilam, A. Dinesh Raja, M. Akiful Haque, Chandan Nayak, Senthilkumar Balakrishnan, Laliteshwar Pratap Singh, Saswati Panigrahi, Mohammed Ali Alshehri, Safia Obaidur Rab, Najmus Sakib Minhaj, Talha Bin Emran   +13 more
wiley   +1 more source

Clinical studies and safety evidence for human consumption of Shilajit: a herbo-mineral compound with multifaceted health benefits [PDF]

Shilajit is one of the ancient and traditional herbo-mineral compounds that has been used for multiple health benefits for centuries. It is associated with potent antioxidant and anti-inflammatory effects via modulation of signaling pathways such as NF ...
Iqubal, Ashif, Qadir, Abdul
core   +2 more sources

Diversity of Alternaria‐derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain

Food Frontiers, Volume 6, Issue 1, Page 185-217, January 2025.
The Alternaria genus includes over 250 fungal species that contaminate crops and food with harmful mycotoxins, posing risks to plant, animal, and human health. This review discusses the classification, impact, and prevalence of Alternaria mycotoxins, their toxicodynamics and toxicokinetics, and highlights the need for regulations and preventive ...
Sarfaraz Hussain, Aqleem Abbas, Maratab Ali, Israt Jahan, Muhammad Jabran, Muhammad Afaq Ahmed, Zienab F. R. Ahmed, Xinhua Zhang   +7 more
wiley   +1 more source

Shilajit Mitigates Diabetes‐Induced Testicular Dysfunction in Mice: A Modulation in Insulin Sensitivity, Germ Cell‐Junctional Dynamics, and Oxido‐Apoptotic Status

Andrologia, Volume 2025, Issue 1, 2025.
Diabetes is a chronic metabolic condition that causes testicular damage by high oxidative stress, rendering 35% of afflicted people infertile. Shilajit is a traditional Indian medicine known for its antioxidant, antidiabetic, and aphrodisiac properties. However, its effectiveness on diabetes‐induced testicular dysfunction remains unclear.
Arti Rajpoot, Ajai Kumar Pandey, Vikas Kumar Roy, Raghav Kumar Mishra, Haney Samir   +4 more
wiley   +1 more source

Biotransformation of 3-hydroxydibenzo-\u3b1-pyrone into 3,8 dihydroxydibenzo-\u3b1-pyrone and aminoacyl conjugates by Aspergillus niger isolated from native "shilajit" [PDF]

, 2009
"Shilajit" is a panacea in Ayurveda, the Indian traditional system of medicine. The major bioactives of "shilajit" have been identified as dibenzo-\u3b1-pyrones (DBPs), its oligomers and aminoacyl conjugated derivatives.
Banerjee, D., Ghosal, S., Ghosh, R., Islam, A., Mazumder, U.K.., Nath, P.   +5 more
core  

Conjugated Shilajit‐Loaded Chitosan Nanoparticles and Alendronate as Regulators for Osteoporosis: The Correlation Between Bone Mineral Density, Immunity, Antioxidants, and Leptin

International Journal of Polymer Science, Volume 2025, Issue 1, 2025.
Shilajit is a multicomponent natural mineral substance that contains more than 85 types of ionic minerals in addition to fulvic and humic acids. Effects of consuming a shilajit‐fortified diet on disease resistance, immune response, and antioxidant activity have been reported. Evidence has proven that it can aid in the treatment of postosteoporosis, but
Fawzia A. Alshubaily, Ebtihaj J. Jambi, Ghulam Md Ashraf, Hamouda M. Mousa   +3 more
wiley   +1 more source

Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC) [PDF]

Endophytic fungi have emerged as a significant source of natural products with remarkable bioactivities. Recent research has identified numerous antioxidant molecules among the secondary metabolites of endophytic fungi.
Asomadu, Rita Onyekachukwu, Ezeorba, Timothy Prince Chidike, Ezike, Tobechukwu Christian, Uzoechina, Jude Obiorah   +3 more
core   +1 more source

Recent Applications of Sulfonium Salts in Synthesis and Catalysis

Chemistry – A European Journal, Volume 30, Issue 70, December 13, 2024.
This review summarizes the recent developments on the synthetic applications of sulfonium salts with an emphasis on the description of the operating mechanistic pathways. Abstract The use of sulfonium salts in organic synthesis has experienced a dramatic increase during the last years that can arguably be attributed to three main factors; the ...
Sven Timmann, Zeyu Feng, Manuel Alcarazo
wiley   +1 more source

Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years

ChemistryOpen, Volume 13, Issue 5, May 2024.
Multicomponent reactions (MCRs) are a valuable strategy toward complex polysubstituted compounds because they simplify long sequences, increasing their efficiency. The total synthesis of natural products achieved since 2004 through the use of three‐component reactions as a strategic MCR approach is reviewed.
Enrique L. Larghi, Andrea B. J. Bracca, Sebastian O. Simonetti, Teodoro S. Kaufman   +3 more
wiley   +1 more source