A drug repurposing screen for whipworms informed by comparative genomics [PDF]
PLoS Negl Trop Dis, 2023 Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Coghlan A +14 more
europepmc +4 more sources
Prevention of the Emergence of Drug Resistance in Bacteria by Acridines, Phenothiazines, and Dibenzocycloheptenes [PDF]
Applied Microbiology, 1966 It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives
C S, Heller, M G, Sevag
core +6 more sources
Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 and Analogues and the Formal Synthesis of (−)-Allocolchicine [PDF]
, 2010 The preparation of dibenzocycloheptyne-Co2(CO)6 complexes by intramolecular Nicholas reactions of biaryl-2-propargyl alcohol-Co2(CO)6 derivatives is described.
Djurdjevic, Sinisa +2 more
core +2 more sources
Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse Agonist Activity
, 2004 This work reports the design and synthesis of novel alkylamides, characterized by a dibenzo- [a,d]cycloheptene nucleus, as melatonin (MLT) receptor ligands.
BEDINI A. +12 more
core +3 more sources
Epidemiología de la tendencia y factores asociados al uso de antidepresivos en adolescentes [PDF]
, 2023 ● ANTECEDENTES. La depresión y ansiedad en adolescentes es particularmente preocupante debido a su impacto en el bienestar emocional, social y académico. El uso de antidepresivos en adolescentes ha aumentado en las últimas décadas, pero su seguridad y
Serrano Aguilar, María
core
Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent
Evidence-Based Complementary and Alternative Medicine, Volume 2017, Issue 1, 2017., 2017 Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one‐third of the world’s population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains.
Shuaibu Babaji Sanusi +5 more
wiley +1 more source
Reduction of Benzylidene Dibenzo[ a, d ]cycloheptenes: Over-Reduction of Antiaromatic Dianions to Aromatic Tetraanions [PDF]
, 2011 The antiaromaticity of a series of dianions of p-substituted benzylidene dibenzo[a,d]cycloheptenes was examined through calculated measures of antiaromaticity.
Higbee, MacDonald +2 more
core +1 more source
, 2016 The preparation of dibenzocycloheptyne-Co2(CO)6 complexes by intramolecular Nicholas reactions of biaryl-2-propargyl alcohol-Co2(CO)6 derivatives is described.
Fei Yang (46361) +2 more
core +2 more sources
Neuropharmacological interactions in the rat pineal gland a study of antidepressant drugs [PDF]
, 1992 The rat pineal gland provides a convenient model for investigating nor adrenergic receptor neurotransmission and the effects of various drugs on these processes in health and disease.
Banoo, Shabir
core +1 more source
The evaluation of melatonin as a possible antidepressive [PDF]
, 1980 Melatonin, a hormone of the pineal gland, was evaluated in a variety of animal models of depression. Measurements of the frog righting reflex and rat locomotor activity showed that low doses of melatonin have a serotonin-like potentiating effect ...
Skene, Debra Jean
core +1 more source