Results 141 to 150 of about 150,124 (289)

Pulso Semanal (9 dic-13 dic, 2019)

, 2019
Publicación que presenta una síntesis de las principales noticias y sucesos de los mercados financieros y bursátiles del mundo ocurridos en la última semana.
openaire   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Electronic Blockade of Shunting Pathways via Dual Insulator Contacts for High-Efficiency Wide-Bandgap Perovskite Indoor Photovoltaics. [PDF]

Nanomicro Lett
Liu Q, Wang Y, Ma Q, Zheng J, Peng Y, Wang L, Chen Z, Du T, Xiao D, Fan J, Hahn YB, Mai Y.   +11 more
europepmc   +1 more source

Pulso Semanal (7 dic.-11 dic.,2020)

, 2020
Publicación que presenta una síntesis de las principales noticias y sucesos de los mercados financieros y bursátiles del mundo ocurridos en la última semana.
openaire   +1 more source

Late‐Stage Modification of Halotryptophan‐Containing Peptides Via Negishi Cross‐Coupling

Chemistry – A European Journal, EarlyView.
Negishi cross‐coupling provides access to the late‐stage functionalization of bromotryptophan‐containing peptides under comparatively mild conditions and is applicable to a range of peptide substrates in the investigated model systems. The examined alkyl iodides and variation of N‐terminal residues demonstrate the feasibility of the transformation in a
Laura Cerveson, Marcel‐Jannik Heldt, Norbert Sewald   +2 more
wiley   +1 more source

Early Prediction of Sepsis-Related Coagulopathy: A Comparative Evaluation of Clinical Scoring Systems in the Emergency Department. [PDF]

J Clin Med
Petrucci M, Gemma S, Iozzia I, Della Polla DA, Bonadia N, Tullo G, Fanelli PMC, Gasbarrini A, Franceschi F, Covino M.   +9 more
europepmc   +1 more source

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

Enhancing phenolic extractability and antioxidant activity in dandelion leaves and roots through instant controlled pressure drop pretreatment. [PDF]

NPJ Sci Food
Macías-Muñoz LF, Cardador-Martínez A, Téllez-Pérez C, Alonzo-Macías M.   +3 more
europepmc   +1 more source

[Compensated DIC].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1986
openaire   +2 more sources

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source