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DICER: structure, function, and regulation [PDF]
Biophysical Reviews, 2021 Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow function and survival of eukaryotic cells. The type III ribonuclease DICER is widely recognized as a key step in the production of miRNAs and siRNAs, although it also has non-canonical functions such as DNA ...
Carlos A. Vergani-Junior +3 more
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Immunohistochemical expression of Dicer in melanoma.
Journal of Clinical Oncology, 20108591 Background: Little is known about Dicer (D) deregulation in tumour development and/or progression although several recent studies show that a decrease in D expression seems to correlate with s...
CAPALBO, CARLO +4 more
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Dicer is essential for neuronal polarity
International Journal of Developmental Neuroscience, 2012AbstractDicer, an RNase III endonuclease, is the enzyme which cleaves microRNA (miRNA) and small interfering RNA (siRNA) precursors into 21–25 nucleotide species. This cleavage is an essential step in the biogenesis of these small noncoding RNA molecules.
Xi He, Zhi Li, Jiexiong Feng
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Nature Plants, 2019
Global analysis revealed extensive uridylation and cytidylation at the 3’ end of plant microRNA precursors.
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Global analysis revealed extensive uridylation and cytidylation at the 3’ end of plant microRNA precursors.
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Science, 2010
An enzyme that cleaves RNA is converted to a DNA-cleaving enzyme during programmed cell death in Caenorhabditis elegans .
Qinghua Liu, Zain Paroo
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An enzyme that cleaves RNA is converted to a DNA-cleaving enzyme during programmed cell death in Caenorhabditis elegans .
Qinghua Liu, Zain Paroo
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Dicer is essential for mouse development
Nature Genetics, 2003To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and,
Alea A. Mills +10 more
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Exosomes-mediated synthetic Dicer substrates delivery for intracellular Dicer imaging detection
Biosensors and Bioelectronics, 2020Ribonuclease Dicer initiates gene-silencing process by cleaving exogenously long RNA duplexes into small interfering RNA (siRNA) or endogenous precursor microRNAs (pre-miRNAs) into mature miRNAs. It holds great promise in cancer diagnosis and therapeutics due to its molecular ruler role.
Wenhao Dai +4 more
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Nature Structural & Molecular Biology, 2006
Recent structures of Dicer and the related bacterial enzyme, RNase III, demonstrate how Dicer acts as a molecular ruler, measuring out a precise length of double stranded RNA before cleavage.
Elena Conti, Atlanta G. Cook
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Recent structures of Dicer and the related bacterial enzyme, RNase III, demonstrate how Dicer acts as a molecular ruler, measuring out a precise length of double stranded RNA before cleavage.
Elena Conti, Atlanta G. Cook
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2021
With the development of increasingly advanced A.I. systems, it has been suggested on several fronts to make use of predictive algorithms in the jurisdictional system, in the analysis of the cases and formulation of decisions, should they be capable of iuris-dicere like human judges.
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With the development of increasingly advanced A.I. systems, it has been suggested on several fronts to make use of predictive algorithms in the jurisdictional system, in the analysis of the cases and formulation of decisions, should they be capable of iuris-dicere like human judges.
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Nature, 2011
An enzyme called Dicer is known for its central role in RNA-controlled gene silencing. Mammalian Dicer1, however, also seems to have another function: it maintains visual health by degrading toxic RNA molecules. See Article p.325 Kaneko et al.
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An enzyme called Dicer is known for its central role in RNA-controlled gene silencing. Mammalian Dicer1, however, also seems to have another function: it maintains visual health by degrading toxic RNA molecules. See Article p.325 Kaneko et al.
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