Results 171 to 180 of about 1,127,048 (333)

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens   +2 more
wiley   +1 more source

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye   +8 more
wiley   +1 more source

A taxonomically harmonized global dataset of wild bird hosts for avian influenza virus surveillance. [PDF]

open access: yesSci Data
Du F   +10 more
europepmc   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj   +6 more
wiley   +1 more source

A deep dictionary clustering approach for unsupervised image retrieval using convolutional sparse coding. [PDF]

open access: yesSci Rep
Sucharitha G   +6 more
europepmc   +1 more source

From Compliance to Collaboration: Towards a Strategic Framework for Social Sustainability in Fashion Supply Chains—Insights From a Two‐Phase Literature Review

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The purpose of this study is to provide a comprehensive longitudinal analysis of the evolution of social sustainability within the global textile and fashion industry across two distinct regulatory eras: post‐Multifibre Agreement (2005–2018) and post‐Modern Slavery Act (2019–2023).
Amanpreet Singh   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy