Results 271 to 280 of about 921,197 (342)

Patient‐derived organoid‐immune co‐cultures integrated with multi‐omics reveal immunotherapy resistance mechanisms in urothelial carcinoma

open access: yesiMeta, EarlyView.
Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the exploration of its role in immune checkpoint inhibitor (ICI) resistance remains scarce, thus impeding a deeper understanding of the tumor immune microenvironment
Shan Jiang   +12 more
wiley   +1 more source

Bidirectional associations between parental negativity and child externalising problems: Social support and neighbourhood cohesion as moderators

open access: yesJCPP Advances, EarlyView.
This study, using data from Avon Longitudinal Study of Parents and Children across ages 4, 7 and 8, found bidirectional associations between parental negativity and child externalising behaviour across ages 7 to 8 but not ages 4 to 7. Contrary to expectations, social support and neighbourhood cohesion did not moderate any of the cross‐lagged paths ...
Jasmine A. L. Raw   +4 more
wiley   +1 more source

Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort

open access: yesJCPP Advances, EarlyView.
Abstract Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which take into account age‐related trends are needed.
Nicky Wright   +13 more
wiley   +1 more source

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