Results 251 to 260 of about 667,864 (326)

Turning the Tables: Leveraging Purpose as a Strategic Advantage for SMEs

open access: yesStrategic Change, EarlyView.
ABSTRACT When executed well, purpose can become a transformative force, turning a business into a breakout success. Despite the wave of purpose‐driven businesses in recent years, the concept of purpose remains underdeveloped. Purpose is a core component of business models but is difficult to retrofit into large corporations, which makes it especially ...
Klaus Heine, Glyn Atwal, Sonja Sperber
wiley   +1 more source

CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

open access: yesMed Research, EarlyView.
ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective,
Jie Yang   +36 more
wiley   +1 more source

Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is characterized by predominantly neuronal α‐synuclein pathology and dopaminergic dysfunction. Cerebrospinal fluid (CSF) seeding amplification assays (SAA) detect α‐synuclein aggregates in vivo, but not all patients with PD have a positive SAA.
Michael Tran Duong   +186 more
wiley   +1 more source

Simultaneous Volumetric T1 and T2 Mapping With Blood‐ and Fat‐Suppression in Abdominal Aortic Aneurysms

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop and validate a protocol for simultaneous volumetric T1 and T2 mapping with blood‐ and fat‐suppression, and apply it to patients with abdominal aortic aneurysms (AAA) to assess tissue characteristics. Methods A spoiled gradient echo (SPGR) variable flip angle (VFA) acquisition was modified with preparation modules to suppress
Wilhelm Stehling   +7 more
wiley   +1 more source

Clinically Feasible White Matter Fiber Tractography in Peritumoral Zones With Cerebral Vasogenic Edema

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose In diffusion MRI, vasogenic edema manifests as a major fraction of isotropic water that dilutes the anisotropic intra‐axonal portion of the signal. Many tractography algorithms mistake vasogenic edema for the white matter boundary and terminate tracking to prevent producing spurious streamlines.
Patryk Filipiak   +6 more
wiley   +1 more source

Harmonizing self-reported and free text medication data: a reproducible pipeline for gerontological research. [PDF]

open access: yesBMC Med Inform Decis Mak
Singh RK   +9 more
europepmc   +1 more source

Optimizing Selective RF Pulses for Enhanced Signal Stability in Turbo Spin Echo Using a Differentiable Extended Phase Graph Model

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To improve slice profile consistency across echo trains in turbo spin echo (TSE) imaging, thereby reducing image blurring and increasing the accuracy of multi echo spin echo T2$$ {T}_2 $$ mapping. Methods Excitation and refocusing RF pulses were optimized for TSE using a differentiable extended phase graph model that incorporates the ...
Madison M. Augelli   +3 more
wiley   +1 more source

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