Results 141 to 150 of about 1,407,930 (315)

A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis [PDF]

, 2006
Background The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization.
Humala Nelson, Suh Jason, Ho Lap, MacGrogan Donal, Voustianiouk Andrei, Lange Dale J, Zhao Zhong, Thiyagarajan Meenakshisundaram, Wang Jun, Pasinetti Giulio M   +9 more
core   +2 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet

Lipids in Health and Disease
Background Ketogenic diets are increasingly popular for addressing obesity, but their impacts on the gut microbiota and metabolome remain unclear. This paper aimed to investigate how a ketogenic diet affects intestinal microorganisms and metabolites in ...
Hongyan Qiu, Chengxia Kan, Fang Han, Youhong Luo, Na Qu, Kexin Zhang, Yanhui Ma, Ningning Hou, Di Wu, Xiaodong Sun, Junfeng Shi   +10 more
doaj   +1 more source

Effects of Ketogenic Diets on Cardiovascular Risk Factors: Evidence from Animal and Human Studies. [PDF]

, 2017
The treatment of obesity and cardiovascular diseases is one of the most difficult and important challenges nowadays. Weight loss is frequently offered as a therapy and is aimed at improving some of the components of the metabolic syndrome.
Jornayvaz, F.R., Kosinski, C.
core   +3 more sources

Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open‐label prospective study

Epilepsia Open, EarlyView.
Abstract Objective CDKL5 deficiency disorder (CDD) is an early‐onset developmental and epileptic encephalopathy characterized by frequent drug‐resistant seizures, cerebral visual impairment, motor dysfunction, and sleep and gastrointestinal disturbances.
Marco Perulli, Alessia De Gioia, Federica Ruggiero, Federica Ascione, Chiara Porto, Elisa Musto, Valentina Massaroni, Maria Picilli, Maria Luigia Gambardella, Michela Quintiliani, Ilaria Contaldo, Chiara Veredice, Domenica Immacolata Battaglia   +12 more
wiley   +1 more source

Implementation of ketogenic diet in children with drug-resistant epilepsy in a medium resources setting: Egyptian experience

Epilepsy and Behavior Case Reports, 2019
Background: Even with the extensive use of ketogenic dietary therapies (KD), there still exist many areas of the world that do not provide these treatments.
Mary Gerges, Laila Selim, Marian Girgis, Amr El Ghannam, Hadeer Abdelghaffar, Ahmed El-Ayadi   +5 more
doaj   +1 more source

Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase–amplitude coupling

Epilepsia Open, EarlyView.
Abstract Objective Treatment selection for infantile epileptic spasms syndrome (IESS) is complex and multifaceted, and currently no electroencephalogram (EEG) biomarkers can guide this decision by predicting treatment response. We tested the predictive value of phase–amplitude coupling (PAC) as IESS patients are known to have elevated PAC.
Soudeh Mostaghimi, Marco A. Pinto‐Orellana, Nathaniel Green, Daniel W. Shrey, Makoto Miyakoshi, Shaun A. Hussain, Beth A. Lopour   +6 more
wiley   +1 more source

Safety and tolerance of the ketogenic diet in patients with Zellweger Syndrome

Epilepsy & Behavior Reports
Zellweger Syndrome is a peroxisomal disorder that can lead to elevation of long chain fatty acids and epilepsy, which can be drug resistant. The treatment of drug resistant epilepsy can include the ketogenic diet in appropriately chosen patients ...
Borst Stephanie, Ciliberto Michael, Thati Ganganna Sreenath   +2 more
doaj   +1 more source

Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]

, 2018
Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus, Karber, Mirjam, Kuhn, Hartmut   +2 more
core   +2 more sources

Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature

Epilepsia Open, EarlyView.
Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat, I‐Chun Lee, Marica Rubino, Vehap Topçu, Melissa Chavez‐Castillo, Shao Ching Tu, Marwan Shinawi, Isabel Alfradique‐Dunham, Manouela Valtcheva, Astrid Adarmes‐Gómez, Daniel Macias‐Garcia, Laura Laura Muñoz‐Delgado, Silvia Jesús, Pablo Mir, Andreas Merkenschlager, Antonietta Coppola   +15 more
wiley   +1 more source