Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, Volume 99, Issue 3, Page 809-824, March 2026.A[Color figure can be viewed at www.annalsofneurology.org] Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone
Soudabeh Naderi +10 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 3, March 2026.This integrated clinical approach optimizes the reproductive cycle in several steps, starting with nutrition (A): restricting carbohydrates and inducing ketosis to reduce inflammation and improve insulin sensitivity, which benefits follicular development.
Tania G. Rojas‐Pérez +7 more
wiley +1 more source
Correction: Ketogenic diet improves disease activity and cardiovascular risk in psoriatic arthritis: A proof of concept study. [PDF]
PLoS OneRamonda R +11 more
europepmc +1 more source
Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures
Annals of the Child Neurology Society, Volume 4, Issue 1, Page 52-63, March 2026.ABSTRACT Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates. We evaluated the safety and efficacy of lacosamide for neonatal seizures. Methods This 10‐center, retrospective study of neonates with seizures
Alexandra Santana Almansa +15 more
wiley +1 more source
The Ketogenic Diet in Type 2 Diabetes and Obesity: A Narrative Review of Clinical Evidence. [PDF]
NutrientsKilian J +4 more
europepmc +1 more source
Advantages of Exome Sequencing Over Panel Testing for Individuals With a Seizure Indication
Annals of the Child Neurology Society, Volume 4, Issue 1, Page 29-37, March 2026.ABSTRACT Objective Our aim was to investigate the advantages of exome sequencing versus panel testing for patients with unexplained seizures. Methods We reviewed the diagnostic outcomes of exome sequencing by a commercial genetics laboratory for more than 16 000 individuals with a clinical history of seizures or suspected seizures.
Michelle M. Morrow +8 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley +1 more source
Exploring the role of gut microbiota in potential mechanism of ketogenic diet in alleviating Parkinson's disease symptoms. [PDF]
Front NeurosciLuo XM +5 more
europepmc +1 more source
The Response of Alpha‐Aminoadipic Acid (2‐AAA) to Short Term Lysine Ingestion in Healthy Individuals
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.Higher circulating levels of the metabolite alpha‐aminoadipic acid (2‐AAA) associate with increased risk of diabetes and cardiometabolic disease. We found that administration of 13C lysine in healthy volunteers associates with inter‐individual variation in lysine‐2‐AAA metabolism and leads to increases in plasma insulin, C‐peptide, glucagon, and GLP‐1 ...
E. Danielle Dean +6 more
wiley +1 more source
The Old and the New: Promising Interventions for Bipolar Disorder Combining Mood-Stabilizing Medication With Nutritional Ketosis. [PDF]
Biol Psychiatry Glob Open SciPhillips ML.
europepmc +1 more source