Results 181 to 190 of about 3,281,487 (298)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Spatiotemporal characterization of ghrelin and cholecystokinin levels in the gastrointestinal tract of juvenile S<i>parus aurata</i>: effects of feeding status and diet composition. [PDF]

Front Endocrinol (Lausanne)
Caderno A, Tang P, de Las Heras V, Gharbi N, Alarcón-López FJ, Mancera JM, Martos-Sitcha JA, Gilannejad N.   +7 more
europepmc   +1 more source

The interactive effects of psychosocial stress and diet composition on health in primates. [PDF]

Neurosci Biobehav Rev, 2023
Shively CA, Frye BM, Negrey JD, Johnson CSC, Sutphen CL, Molina AJA, Yadav H, Snyder-Mackler N, Register TC.   +8 more
europepmc   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Diet composition impacts the natural history of steatotic liver disease. [PDF]

Hepatol Commun
Callans LE, Ivey KL, Chang KM, Kaplan DE, Kaplan DE, VA Million Veteran Program.   +5 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Diet composition affects bat viral shedding with potential consequences for pathogen spillover. [PDF]

Proc Biol Sci
Vanalli C, Falvo C, Crowley D, Schwarz B, Plowright R, Hudson PJ, Rynda-Apple A, Cattadori IM.   +7 more
europepmc   +1 more source

THE RELATION OF THE DIET TO THE COMPOSITION OF TISSUE PHOSPHOLIPIDS

Journal of Biological Chemistry, 1943
Camillo Artom, William H. Fishman
openaire   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Temporal Patterns of Eating and Diet Composition of Night Shift Workers Are Influenced More by Shift Type than by Chronotype. [PDF]

Nutrients
Phoi YY, Dorrian J, Rogers M, Leung GKW, Davis R, Clark AB, Davis C, Bonham MP, Coates AM.   +8 more
europepmc   +1 more source