Results 51 to 60 of about 14,002 (252)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function

Chronic Diseases and Translational Medicine, EarlyView.
Flowchart of patient enrollment. ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy).
Xiaohui Dou, Xijuan Zhang, Liang Zeng, Liheng Zeng, Xiaoyan Hu, Xuhong Jiang, Yahui Wan, Mingxia Ge, Xiaoyan Huang   +8 more
wiley   +1 more source

Green Tea Extract Decreases the Systemic Exposure of Pazopanib in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Green tea catechins modulate the activity of key drug pharmacokinetic determinants and consequently, concomitant consumption of green tea can significantly alter systemic drug exposure. This study aimed to investigate the influence of concomitant green tea catechin consumption on the pharmacokinetics of pazopanib, a tyrosine kinase inhibitor used in ...
Nicki M. Kyriacou, Annette S. Gross, Thomas M. Polasek, Xiaosuo Wang, Andrew J. McLachlan   +4 more
wiley   +1 more source

Adherence to the DASH diet moderates the association between sedentary time and the risk of obstructive sleep apnea in a hypertensive rural Chinese population: a cross-sectional study

Scientific Reports
Obstructive sleep apnea (OSA) and hypertension form a vicious cycle. While sedentary behavior is an emerging risk factor for OSA, and the dietary approaches to stop hypertension (DASH) diet offers cardiometabolic benefits, their interplay in non-obese ...
Yong Lin, Lijuan Bao, Yanli Zhao, Shaolian Huang, Yuhua Ruan, Li Wang, Yi Chen   +6 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome

Nature Communications
The interplay between diet and gut microbiome composition is complex. Faecal metabolites, the end products of human and microbial metabolism, provide insights into these interactions.
Robert Pope, Alessia Visconti, Xinyuan Zhang, Panayiotis Louca, Andrei-Florin Baleanu, Yu Lin, Francesco Asnicar, Kate Bermingham, Kari E. Wong, Gregory A. Michelotti, Jonathan Wolf, Nicola Segata, Sarah E. Berry, Tim D. Spector, Emily R. Leeming, Rachel Gibson, Cristina Menni, Mario Falchi   +17 more
doaj   +1 more source

Advance in Epidemiologic Studies of Dietary Patterns Associated with Cerebrovascular Diseases [PDF]

Zhongguo quanke yixue
Stroke has become the leading cause of death in China, and rational diet is an important primary prevention strategy, but the optimal dietary pattern remains to be studied.
CHEN Wenjin, CHEN Piaoying, YANG Xiaohua, CHEN Yifan, CAI Yefeng, NI Xiaojia
doaj   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Which Is More Effective in Hypertension?: Salt-Free Diet vs. Dietary Approaches to Stop Hypertension (DASH) Diet

, 2022
Abstract Background: Although there is strong evidence that the DASH diet lowers blood pressure in national guideline recommendations, the studyresults are still uncertain. Aims: In this randomized controlled intervention study, it was aimed to compare the effects of the DASH diet and salt-free diet on blood pressure.
aslı çapar, Müge Yılmaz
openaire   +1 more source