Results 161 to 170 of about 289,473 (283)

Macrophage Derived Galectin‐3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived Galectin‐3 amplifies TGFβ1 signaling to drive diabetic kidney fibrosis: a novel therapeutic target. Abstract Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease.
Yibing Chen   +17 more
wiley   +1 more source

Autophagy‐Mediated Suppression of Tumor Growth by Food‐Grade Lipid Nanoparticles in Mice

open access: yesAdvanced Science, EarlyView.
This work reveals a novel extracellular nanoparticle transport and metabolic pathway. Following cellular uptake, Food‐grade lipid nanoparticles (FLNs) selectively fuse with lipid droplets (LDs) rather than lysosomes, driving LDs accumulation. This process activates autophagy through the AMPK‐mTOR‐ULK1 signaling axis, facilitating tumor progression ...
Chenglu Peng   +10 more
wiley   +1 more source

Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists. [PDF]

open access: yesInnate Immun, 2023
Shehat MG   +4 more
europepmc   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

open access: yesAdvanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim   +9 more
wiley   +1 more source

Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women. [PDF]

open access: yesJ Nutr, 2023
Prentice RL   +20 more
europepmc   +1 more source

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