Results 151 to 160 of about 170,663 (278)

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino   +2 more
wiley   +1 more source

Evaluating digital cognitive tests for clinical use in Alzheimer's disease: A novel framework and scoping review

open access: yesAlzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self‐administered digital cognitive assessments (SA‐DCAs) offer scalable approaches for early detection, yet their real‐world validation and clinical readiness ...
Harald Hampel   +10 more
wiley   +1 more source

Examining the Psychometric Properties of Four Mattering Constructs Through Rasch Modeling: Evidence From Turkish Adolescents and College Students

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
This study examined the psychometric properties of four mattering constructs—general mattering, anti‐mattering, online mattering, and online anti‐mattering—among Turkish adolescents and college students. Using data from 888 participants, the researchers applied confirmatory factor analyses to test the dimensional structure and reliability of the scales,
Alican Kaya   +6 more
wiley   +1 more source

Cytokine Gene Variants Are Associated With Aerobic Fitness‐Related, Hematological, and Metabolic Traits in Healthy Adults

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Analysis of ~1000 adults shows cytokine gene variants are more strongly associated with hematological and metabolic traits than fitness classification. IL6 and TNF‐α variants link to iron status and aerobic fitness, with exploratory multi‐locus effects involving IL15. ABSTRACT Genetic variation in cytokine genes may influence cytokine‐related signaling,
Kinga Humińska‐Lisowska   +6 more
wiley   +1 more source

Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes

open access: yesGlia, Volume 74, Issue 8, August 2026.
Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi   +9 more
wiley   +1 more source

Clinicopathological Features of Lupus Erythematosus Panniculitis (LEP): A Retrospective Analysis of 54 Cases

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Lupus Erythematosus Panniculitis (LEP) is a rare subtype of Cutaneous Lupus Erythematosus. It is a challenging disease to diagnose and treat due to limited understanding of its clinical and histopathological characteristics. Methods We conducted a retrospective review of 54 biopsy‐proven LEP cases evaluated at a dermatology referral
Maryam Nasimi   +7 more
wiley   +1 more source

BODY‐Q‐7D Measures Consensus‐Based Patient‐Reported Outcomes for the Management of Obesity Treatment

open access: yesObesity, Volume 34, Issue 8, Page 1600-1612, August 2026.
ABSTRACT Objective A global multidisciplinary consensus initiative identified eight patient‐reported outcome domains important in obesity care: self‐esteem; physical, mental, and social health; eating; stigma; body image; and excess skin. Several of these domains are not represented in generic preference‐based measures typically used in weight loss ...
Anne F. Klassen   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy