Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Has the consistency evaluation policy of generic drugs promoted the innovation quality of Chinese pharmaceutical manufacturing industry? An empirical study based on the difference-in-differences model. [PDF]
Front Public Health, 2023 Liu Q, Huang Z, Mao Z.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
How China's Great Bay Area Policies Affect the National Identity of Hong Kong Youth-A Study of a Quasi-Natural Experiment Based on the Difference-in-Differences Model. [PDF]
Behav Sci (Basel), 2023 Fu C, Liao L, Mo T, Chen X.
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
MC1 THE EFFECT OF MEDICAID EXPANSION ON CANCER SCREENING RATE: A DIFFERENCE-IN-DIFFERENCE-IN-DIFFERENCE MODEL [PDF]
Value in Health, 2020 Y. Shao, C. Stoecker
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AtmosphereCarbon emissions trading policy is an important tool to achieve carbon peaking and carbon neutrality goals. In order to explore the effectiveness of carbon emissions trading policy, this paper adopts the difference-in-differences model to analyze the ...
Hui Zhang, Xiuying Lv
doaj +1 more source
Risk Management and Healthcare Policy, 2023 Chunbo Gong, Huaixing Kang ShanDong University of Traditional Chinese Medicine, JiNan, 250355, People’s Republic of ChinaCorrespondence: Huaixing Kang, Email Huaixingkang@outlook.comIntroduction: The study proposes a method based on difference-in ...
Gong C, Kang H
doaj